{"id":"ddb5b2e3-d136-5a6a-a8ea-ace31821410f","stable_key":"96d9034a-2550-5f3c-b767-1767c982533c:lariciresinol-moves-glut4-and-raises-glucose-uptake","predicate":"increases","statement":"In C2C12 myotubes lariciresinol activated insulin signalling leading to GLUT4 translocation and augmented glucose uptake.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"b6ba3b4c-6978-5986-9241-0c3f4d580108","mechanism_event_label":"In C2C12 myotubes lariciresinol activated insulin signalling leading to GLUT4 translocation and augmented glucose uptake.","subject":{"id":"4fcf5405-bafb-54bf-89b8-2fc11e0d9822","slug":"lariciresinol","display_name":"Lariciresinol, enantiomer unresolved","entity_type_key":"small_molecule"},"object":{"id":"b87686d5-bf72-5106-b255-c351baca4694","slug":"c2c12-glut4-translocation","display_name":"GLUT4 translocation in C2C12 myotubes","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b6ba3b4c-6978-5986-9241-0c3f4d580108","stable_key":"96d9034a-2550-5f3c-b767-1767c982533c:lariciresinol-moves-glut4-and-raises-glucose-uptake-event","event_type":"observed_relationship","label":"In C2C12 myotubes lariciresinol activated insulin signalling leading to GLUT4 translocation and augmented glucose uptake.","description":"In C2C12 myotubes lariciresinol activated insulin signalling leading to GLUT4 translocation and augmented glucose uptake.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4fcf5405-bafb-54bf-89b8-2fc11e0d9822","slug":"lariciresinol","display_name":"Lariciresinol, enantiomer unresolved","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b87686d5-bf72-5106-b255-c351baca4694","slug":"c2c12-glut4-translocation","display_name":"GLUT4 translocation in C2C12 myotubes","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Not stated here","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"C2C12 myotubes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Lariciresinol","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The enantiomer and the concentrations are not stated in the abstract. The abstract describes insulin signalling and GSK-3β and does not report AMPK.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"C2C12 myotubes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"In C2C12 myotubes lariciresinol activated insulin signalling leading to GLUT4 translocation and augmented glucose uptake.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Lariciresinol Displays Anti-Diabetic Activity through Inhibition of α-Glucosidase and Activation and Enhancement of Insulin Signaling. (2022). https://pubmed.ncbi.nlm.nih.gov/35490401/ DOI: 10.1002/mnfr.202100910","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Insulin signalling and glucose transporter translocation","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"46e63cd9-c46a-5bec-a23f-f9942672eef4","evidence_kind":"source_excerpt","locator":"Lines 176-185","start_line":176,"end_line":185,"excerpt":"## lariciresinol-moves-glut4-and-raises-glucose-uptake\nIn C2C12 myotubes lariciresinol activated insulin signalling leading to GLUT4 translocation and augmented glucose uptake.\nModel/species: C2C12 myotubes\nTissue/system: Insulin signalling and glucose transporter translocation\nExposure: Lariciresinol\nRoute: In vitro\nDuration: Not stated here\nLimits: The enantiomer and the concentrations are not stated in the abstract. The abstract describes insulin signalling and GSK-3β and does not report AMPK.\nPrimary reference: Lariciresinol Displays Anti-Diabetic Activity through Inhibition of α-Glucosidase and Activation and Enhancement of Insulin Signaling. (2022). https://pubmed.ncbi.nlm.nih.gov/35490401/ DOI: 10.1002/mnfr.202100910\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"48c58761-0291-5bad-a926-75e904b2d802","stable_key":"import-96d9034a-2550-5f3c-b767-1767c982533c","title":"Lariciresinol: five molecules under one name, and the mechanisms each one carries (2026-09-22)","document_type":"imported_text","citation_label":"Original AI-assisted curation of twelve primary studies, every abstract read and all DOIs cross-checked against live PubMed metadata. Mechanism edges only, with no conclusion or claim of benefit recorded. Three author clusters account for eight of the twelve and carry shared laboratory keys. Study-specific concentrations, negative findings and limitations retained. Not publisher full text.","file_path":"","sha256":"6bf0015b7ff727b7a80d693dd18ffdd227d0e16ae45d9e85a5f81fa733edd3a4","revision_id":"219d9b0c-1a71-5e27-8d6c-7b3e77a594c6","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}