{"id":"dd90ab21-5322-50b4-842b-cff87094b43f","stable_key":"3ad23a58-d6a8-5554-81d6-9c83abd33087:znt8-human-protection","predicate":"reported_comparison","statement":"Across approximately 150,000 people, carriers of 12 rare SLC30A8 truncating variants had 65% lower type 2 diabetes risk.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"090d8df1-ba10-5b4f-a020-b9125cf3e6bb","mechanism_event_label":"Across approximately 150,000 people, carriers of 12 rare SLC30A8 truncating variants had 65% lower type 2 diabetes risk.","subject":{"id":"49a6c4a6-bbe2-550b-8f41-dafb5e33bd67","slug":"human-slc30a8-truncating-genotype","display_name":"Human SLC30A8 protein-truncating variant carrier state","entity_type_key":"gene"},"object":{"id":"6055bc93-5c97-50e4-8b6f-9ca9b488fa8f","slug":"type-2-diabetes-incidence","display_name":"Incidence of type 2 diabetes","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"090d8df1-ba10-5b4f-a020-b9125cf3e6bb","stable_key":"3ad23a58-d6a8-5554-81d6-9c83abd33087:znt8-human-protection","event_type":"reported_comparison","label":"Across approximately 150,000 people, carriers of 12 rare SLC30A8 truncating variants had 65% lower type 2 diabetes risk.","description":"","status":"provisional","compartment":null,"participants":[{"entity":{"id":"49a6c4a6-bbe2-550b-8f41-dafb5e33bd67","slug":"human-slc30a8-truncating-genotype","display_name":"Human SLC30A8 protein-truncating variant carrier state","entity_type_key":"gene"},"role":"experimental_actor","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6055bc93-5c97-50e4-8b6f-9ca9b488fa8f","slug":"type-2-diabetes-incidence","display_name":"Incidence of type 2 diabetes","entity_type_key":"cellular_process"},"role":"measured_endpoint","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"a4da847b-7430-527e-bc73-8d17fd5255ba","slug":"slc30a8","display_name":"Human zinc transporter ZnT8 / SLC30A8","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"0429f0ff-c033-514b-9a4f-6f0f83268095","slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"curation_topic","value_text":"zinc","comparator":null,"unit":null,"notes":"","entity":{"slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"}},{"dimension":"experimental_condition","value_text":"Truncating-variant carrier","comparator":"Noncarrier","unit":null,"notes":"Condition belongs to the full experimental contrast; do not separate a joint intervention.","entity":{"slug":"human-slc30a8-truncating-genotype","display_name":"Human SLC30A8 protein-truncating variant carrier state","entity_type_key":"gene"}},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"Truncating-variant carrier\", \"comparator\": \"Noncarrier\", \"endpoint\": \"T2D risk\", \"effect_direction\": \"decrease\", \"combination\": \"single\", \"conditions\": [{\"entity_slug\": \"human-slc30a8-truncating-genotype\", \"state\": \"Truncating-variant carrier\"}]}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"Human genetic association across five ancestry groups","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Publisher abstract reviewed; genetic transporter loss is not dietary zinc restriction or a demonstrated supplement effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Flannick et al. 2014; DOI:10.1038/ng.2915; PMCID:PMC4051628; https://www.nature.com/articles/ng.2915","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"38cc0475-18e2-5ecb-9a02-8f8baf4502f4","evidence_kind":"source_excerpt","locator":"Lines 6-6","start_line":6,"end_line":6,"excerpt":"Across approximately 150,000 people, carriers of 12 rare SLC30A8 truncating variants had 65% lower type 2 diabetes risk. Model: Human genetic association across five ancestry groups. Limits: Publisher abstract reviewed; genetic transporter loss is not dietary zinc restriction or a demonstrated supplement effect. Primary reference: Flannick et al. 2014; DOI:10.1038/ng.2915; PMCID:PMC4051628; https://www.nature.com/articles/ng.2915","model_system":"Human genetic association across five ancestry groups","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Curator paraphrase of the cited primary result; see stated access scope.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"8600b90c-477e-569e-9666-09321af7bc9e","stable_key":"import-3ad23a58-d6a8-5554-81d6-9c83abd33087","title":"Diabetes cascade: targeted primary-source supplement","document_type":"imported_text","citation_label":"See claim-local references; curated paraphrases reviewed 2026-09-20.","file_path":"","sha256":"0a841d67ea40a5efea21157e1a5703488b8ef63e587eea50dacac19c67894cd4","revision_id":"0faa1a78-e820-559e-a23b-5e3939f9079e","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}