{"id":"dd7210a4-190d-500d-80a4-6deb477cf74a","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-iron-fenton","predicate":"inhibits","statement":"Luteolin suppressed Fenton radical generation through combined Fe(II) chelation and radical scavenging.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"c3f78c0f-4197-5b30-bcce-2e0ef901f8a8","mechanism_event_label":"Metal binding and radical chemistry can act together.","subject":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"object":{"id":"557653d3-0a3d-5de0-9b75-a7194da1ec95","slug":"iron-fenton-radical-generation","display_name":"Iron-driven Fenton radical generation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c3f78c0f-4197-5b30-bcce-2e0ef901f8a8","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-iron-fenton-event","event_type":"observed_relationship","label":"Metal binding and radical chemistry can act together.","description":"Luteolin suppressed Fenton radical generation through combined Fe(II) chelation and radical scavenging.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"557653d3-0a3d-5de0-9b75-a7194da1ec95","slug":"iron-fenton-radical-generation","display_name":"Iron-driven Fenton radical generation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"59d6d1cd-df32-5b58-b950-3188bc7b95d6","slug":"iron-ii","display_name":"Ferrous iron","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cell-free chemical system.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a human nutrient requirement or treatment for iron overload.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Luteolin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Metal binding and radical chemistry can act together.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Spectroscopic and electrochemical studies on the evaluation of the radical scavenging activities of luteolin by chelating iron · 2014 · https://pubs.rsc.org/en/content/articlelanding/2014/ra/c4ra01396d · DOI 10.1039/C4RA01396D","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b02b3e28-5bf1-5a8a-b675-ba41f425dae8","evidence_kind":"source_excerpt","locator":"Lines 308-314","start_line":308,"end_line":314,"excerpt":"## luteolin-iron-fenton\nMetal binding and radical chemistry can act together.\nLuteolin suppressed Fenton radical generation through combined Fe(II) chelation and radical scavenging.\nModel: Cell-free chemical system.\nLimitations: Not a human nutrient requirement or treatment for iron overload.\nEvidence access: Primary abstract\nSpectroscopic and electrochemical studies on the evaluation of the radical scavenging activities of luteolin by chelating iron · 2014 · https://pubs.rsc.org/en/content/articlelanding/2014/ra/c4ra01396d · DOI 10.1039/C4RA01396D","model_system":"Cell-free chemical system.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"26337a08-5cee-5cee-900e-e6d3e26ac6e4","stable_key":"import-22527305-af1f-536a-b419-7e73f08cc3ec","title":"Luteolin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"fd6ea0b1cef8d1c9965270494bfa815de14f679044f0b5d5d7bbf4904630ad76","revision_id":"c9a3dd80-c7e6-5fb4-bc91-8db265e7c8de","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}