{"id":"dd65fa29-d266-5ef5-8dac-55d8fb42e9d3","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-clin-esod-zinc","predicate":"was_followed_by_decrease_in","statement":"After ten weeks, erythrocyte Cu/Zn-superoxide dismutase activity was lower than pretreatment in both the zinc-only and zinc-plus-iron groups (P<0.05).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"91f52506-09bc-56b7-8375-13cf23328b4f","mechanism_event_label":"Adding iron did not prevent the fall in this copper/zinc enzyme marker.","subject":{"id":"8410d352-35ea-518e-b738-4c10962b11ed","slug":"zinc-gluconate","display_name":"Zinc gluconate","entity_type_key":"chemical_species"},"object":{"id":"09fadb77-b222-5d11-b365-077675f16d13","slug":"erythrocyte-cu-zn-sod-activity","display_name":"Erythrocyte copper/zinc superoxide dismutase activity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"91f52506-09bc-56b7-8375-13cf23328b4f","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-clin-esod-zinc-event","event_type":"observed_intervention","label":"Adding iron did not prevent the fall in this copper/zinc enzyme marker.","description":"After ten weeks, erythrocyte Cu/Zn-superoxide dismutase activity was lower than pretreatment in both the zinc-only and zinc-plus-iron groups (P<0.05).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9f0afdde-1ec1-5c8a-bb5e-f3b2b75f67f6","slug":"copper","display_name":"Copper","entity_type_key":"nutrient_element"},"role":"affected_nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"coadministered_nutrient","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"49c806c2-7041-5020-8b3b-fa04ffa122ac","slug":"zinc-ion","display_name":"Zinc(II) ion","entity_type_key":"ion"},"role":"administered_element","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"8410d352-35ea-518e-b738-4c10962b11ed","slug":"zinc-gluconate","display_name":"Zinc gluconate","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"09fadb77-b222-5d11-b365-077675f16d13","slug":"erythrocyte-cu-zn-sod-activity","display_name":"Erythrocyte copper/zinc superoxide dismutase activity","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Copper (affected_nutrient); Iron (coadministered_nutrient); Zinc(II) ion (administered_element)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Indexed primary abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/zinc-clinical-sources/yadrick1989.abstract.txt\", \"locator\": \"Primary indexed abstract; complete local file\", \"file_sha256\": \"e2d70d43dded75edb026cac237f238d9e59399db6094098796e169f20e819443\", \"utf8_bytes\": 969}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Ten-week zinc or zinc-plus-iron intervention in adult women","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"50 mg elemental zinc/day as gluconate, with or without 50 mg iron/day as ferrous sulfate monohydrate.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Reported comparisons are within-group pretreatment versus 10 weeks, not placebo-adjusted effects. ESOD is a functional biomarker, not a diagnosis of symptomatic copper deficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Zinc research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Adding iron did not prevent the fall in this copper/zinc enzyme marker.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[zn-clin-yadrick1989] Iron, copper, and zinc status: response to supplementation with zinc or zinc and iron in adult females. (1989). https://pubmed.ncbi.nlm.nih.gov/2912000/ DOI: 10.1093/ajcn/49.1.145","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Blood and erythrocytes","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"30a26f9a-8e61-5b19-8b14-455fed3593ca","evidence_kind":"source_excerpt","locator":"Lines 1181-1194","start_line":1181,"end_line":1194,"excerpt":"### zn-clin-esod-zinc\nAfter ten weeks, erythrocyte Cu/Zn-superoxide dismutase activity was lower than pretreatment in both the zinc-only and zinc-plus-iron groups (P<0.05).\nCondition category: normal\nnutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Adding iron did not prevent the fall in this copper/zinc enzyme marker.\norganism: Homo sapiens\ntissue_or_cell_type: Blood and erythrocytes\nexperimental_model: Ten-week zinc or zinc-plus-iron intervention in adult women\nlimitations: Reported comparisons are within-group pretreatment versus 10 weeks, not placebo-adjusted effects. ESOD is a functional biomarker, not a diagnosis of symptomatic copper deficiency.\nexposure: 50 mg elemental zinc/day as gluconate, with or without 50 mg iron/day as ferrous sulfate monohydrate.\ncross_nutrient: Copper (affected_nutrient); Iron (coadministered_nutrient); Zinc(II) ion (administered_element)\nevidence_location: Indexed primary abstract.\nevidence_span: {\"source_cache\": \"artifacts/zinc-clinical-sources/yadrick1989.abstract.txt\", \"locator\": \"Primary indexed abstract; complete local file\", \"file_sha256\": \"e2d70d43dded75edb026cac237f238d9e59399db6094098796e169f20e819443\", \"utf8_bytes\": 969}\n[zn-clin-yadrick1989] Iron, copper, and zinc status: response to supplementation with zinc or zinc and iron in adult females. (1989). https://pubmed.ncbi.nlm.nih.gov/2912000/ DOI: 10.1093/ajcn/49.1.145","model_system":"Ten-week zinc or zinc-plus-iron intervention in adult women","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [zn-clin-yadrick1989] Iron, copper, and zinc status: response to supplementation with zinc or zinc and iron in adult females. (1989). https://pubmed.ncbi.nlm.nih.gov/2912000/ DOI: 10.1093/ajcn/49.1.145","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c5ee0fee-ce5c-58de-905a-10fb0ea0723c","stable_key":"import-6d38d43e-01e4-5641-93be-65654271e242","title":"Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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