{"id":"dd20ba7d-6886-5a90-becd-21bda2e8480b","stable_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:peroneal-decrease","predicate":"decreases_in_recorded_experiment","statement":"Peroneal sympathetic nerve activity during tilt was attenuated after modafinil despite increased resting cardiovascular measures.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"025ff3d8-5154-50c4-b6d6-5d3a7c26e5ce","mechanism_event_label":"Peroneal sympathetic nerve activity during tilt was attenuated after modafinil despite increased resting cardiovascular measures.","subject":{"id":"624e6a4b-f96d-5d12-8206-30d1e1715c26","slug":"modafinil","display_name":"Modafinil","entity_type_key":"drug"},"object":{"id":"c52e6f55-e529-5617-9248-6cadc276567c","slug":"human-peroneal-sympathetic-activity","display_name":"Human peroneal sympathetic nerve activity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"025ff3d8-5154-50c4-b6d6-5d3a7c26e5ce","stable_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:peroneal-decrease-event","event_type":"experimental_observation","label":"Peroneal sympathetic nerve activity during tilt was attenuated after modafinil despite increased resting cardiovascular measures.","description":"A controlled 12-person human study found increased resting heart rate and blood pressure and higher catecholamine measures after modafinil. However, measured peroneal sympathetic nerve activity during tilt was attenuated. This is a differentiated autonomic response, not every sympathetic output increasing together. Arousal and individual cardiovascular endpoints need separate records. [Autonomic study](https://pubmed.ncbi.nlm.nih.gov/15753235/)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"624e6a4b-f96d-5d12-8206-30d1e1715c26","slug":"modafinil","display_name":"Modafinil","entity_type_key":"drug"},"role":"tested factor","stoichiometry":null,"state_label":"Modafinil with tilt","sequence_order":0,"notes":""},{"entity":{"id":"c52e6f55-e529-5617-9248-6cadc276567c","slug":"human-peroneal-sympathetic-activity","display_name":"Human peroneal sympathetic nerve activity","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"decrease","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary indexed abstract checked; full methods and figures not comprehensively reviewed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"Modafinil with tilt\", \"comparator\": \"Control with tilt\", \"endpoint\": \"Peroneal sympathetic nerve activity during tilt was attenuated after modafinil despite increased resting cardiovascular measures.\", \"effect_direction\": \"decrease\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"Human autonomic experiment; tilt nerve recording versus resting heart rate/BP are separate endpoints.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Peroneal sympathetic nerve activity during tilt was attenuated after modafinil despite increased resting cardiovascular measures.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Modafinil elicits sympathomedullary activation. | 2005 | DOI 10.1161/01.hyp.0000158267.66763.63 | PMID 15753235 | https://pubmed.ncbi.nlm.nih.gov/15753235/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 140-140; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6f11f397-9ba4-5333-b68d-3cd0c94e1931","evidence_kind":"source_excerpt","locator":"Lines 140-140","start_line":140,"end_line":140,"excerpt":"A controlled 12-person human study found increased resting heart rate and blood pressure and higher catecholamine measures after modafinil. However, measured peroneal sympathetic nerve activity during tilt was attenuated. This is a differentiated autonomic response, not every sympathetic output increasing together. Arousal and individual cardiovascular endpoints need separate records. [Autonomic study](https://pubmed.ncbi.nlm.nih.gov/15753235/)","model_system":"Human autonomic experiment; tilt nerve recording versus resting heart rate/BP are separate endpoints.","directness":"reported_statement","verification_status":"source_recorded","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. Not a verbatim quotation from a primary paper.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"17a64928-eaa2-5117-ba4f-52dcbdf9cc9e","stable_key":"import-6660bba2-4fa0-590a-bf52-9803a24bea9f","title":"Modafinil: detailed mechanisms of action (reviewed 3 October 2026)","document_type":"imported_text","citation_label":"Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication.","file_path":"","sha256":"006008cb4cfd183dd3b0846d3abc66c8ebf40cf1b6bd1f0bcdb4f4d937a8e115","revision_id":"c85b3e2e-c18a-59fc-9e79-5c375e64d119","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}