{"id":"dd199697-b586-52c7-8873-1fe994219edf","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:e-clin-adequate-infant-feeds","predicate":"adequate_feeding_prevents_observed_deficiency","statement":"No infant developed clinical or hematological vitamin E-deficiency signs during the ten-week trial when feeds maintained the reported E:PUFA balance and no supplemental iron was given.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"9dc607d7-fedb-5a21-adae-4a7cf5b0f817","mechanism_event_label":"Early anemia was not automatically a vitamin E-shortage syndrome under these feeding conditions.","subject":{"id":"e67a0437-6900-5f53-8b03-c0a7ad6d92b6","slug":"vitamin-e","display_name":"Vitamin E","entity_type_key":"chemical_species"},"object":{"id":"cbf881ed-6411-562e-aa0a-1ec680e866cf","slug":"premature-infant-anemia","display_name":"Premature-infant anemia","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9dc607d7-fedb-5a21-adae-4a7cf5b0f817","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:e-clin-adequate-infant-feeds-event","event_type":"observed_intervention","label":"Early anemia was not automatically a vitamin E-shortage syndrome under these feeding conditions.","description":"No infant developed clinical or hematological vitamin E-deficiency signs during the ten-week trial when feeds maintained the reported E:PUFA balance and no supplemental iron was given.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9f0f7d2e-c307-5413-906c-e07d80435066","slug":"polyunsaturated-fatty-acids","display_name":"Polyunsaturated fatty acids","entity_type_key":"lipid"},"role":"dietary_fat_context","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e67a0437-6900-5f53-8b03-c0a7ad6d92b6","slug":"vitamin-e","display_name":"Vitamin E","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"cbf881ed-6411-562e-aa0a-1ec680e866cf","slug":"premature-infant-anemia","display_name":"Premature-infant anemia","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"true","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Ten-week double-blind feeding trial; 42 premature infants","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Placebo, 5 or 15 mg/day extra vitamin E; all feeds had E:PUFA at least 0.6, and no supplemental iron was given.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"These findings are bounded by the contemporary feeds and absence of supplemental iron; they do not refute hemolysis in actual vitamin E deficiency. The design does not isolate iron as a causal modifier or establish the reported ratio as a universal recommendation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin E research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-e","display_name":"Vitamin E","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Early anemia was not automatically a vitamin E-shortage syndrome under these feeding conditions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[e-clin-neonatal1987] The early anaemia of the premature infant: is there a place for vitamin E supplementation? (1986). https://pubmed.ncbi.nlm.nih.gov/3676185/ DOI: 10.1079/bjn19860090","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Blood and erythrocytes","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"bc4eb5a0-b287-52dd-825a-4a1621ea2c1b","evidence_kind":"source_excerpt","locator":"Lines 1219-1230","start_line":1219,"end_line":1230,"excerpt":"### e-clin-adequate-infant-feeds\nNo infant developed clinical or hematological vitamin E-deficiency signs during the ten-week trial when feeds maintained the reported E:PUFA balance and no supplemental iron was given.\nCondition category: normal\nnutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Early anemia was not automatically a vitamin E-shortage syndrome under these feeding conditions.\norganism: Homo sapiens\ntissue_or_cell_type: Blood and erythrocytes\nexperimental_model: Ten-week double-blind feeding trial; 42 premature infants\nlimitations: These findings are bounded by the contemporary feeds and absence of supplemental iron; they do not refute hemolysis in actual vitamin E deficiency. The design does not isolate iron as a causal modifier or establish the reported ratio as a universal recommendation.\nexposure: Placebo, 5 or 15 mg/day extra vitamin E; all feeds had E:PUFA at least 0.6, and no supplemental iron was given.\ncross_nutrient: true\n[e-clin-neonatal1987] The early anaemia of the premature infant: is there a place for vitamin E supplementation? (1986). https://pubmed.ncbi.nlm.nih.gov/3676185/ DOI: 10.1079/bjn19860090","model_system":"Ten-week double-blind feeding trial; 42 premature infants","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [e-clin-neonatal1987] The early anaemia of the premature infant: is there a place for vitamin E supplementation? (1986). https://pubmed.ncbi.nlm.nih.gov/3676185/ DOI: 10.1079/bjn19860090","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3ac41dba-4727-5116-a556-ac3bbb0dc41c","stable_key":"import-e0ea2d6a-7429-5e9f-b774-41e5e3288da3","title":"Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a90b6565e092c6a2da07f74cf758792c2cf63b40746260c8ff12bd64322c36f4","revision_id":"956793d1-23e4-5397-9291-25c1732a8e02","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}