{"id":"dcabd42f-f835-53c0-ab98-a8fb25da0006","stable_key":"475ea55a-65e9-51c3-a539-738a6a8f683f:mangiferin-insulin-context","predicate":"increases_conditionally","statement":"In insulin-resistant L6 cells, mangiferin increased glucose consumption only with insulin co-treatment; norathyriol worked with or without insulin.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"39785904-beaa-525a-8ef5-cbd736837e44","mechanism_event_label":"The parent compound and metabolite differed under insulin resistance.","subject":{"id":"2cfc0bd9-b5cc-58ab-852a-7705f3d8d47f","slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"},"object":{"id":"04e6c28e-10e0-58fe-9417-371d950bfb0f","slug":"rat-l6-glucose-consumption","display_name":"Rat L6 myotube glucose consumption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"39785904-beaa-525a-8ef5-cbd736837e44","stable_key":"475ea55a-65e9-51c3-a539-738a6a8f683f:mangiferin-insulin-context-event","event_type":"biochemical_relationship","label":"The parent compound and metabolite differed under insulin resistance.","description":"In insulin-resistant L6 cells, mangiferin increased glucose consumption only with insulin co-treatment; norathyriol worked with or without insulin.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d0f7f42a-ac45-5144-9ea5-a7586896cc6e","slug":"norathyriol","display_name":"Norathyriol","entity_type_key":"small_molecule"},"role":"comparator","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2cfc0bd9-b5cc-58ab-852a-7705f3d8d47f","slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"04e6c28e-10e0-58fe-9417-371d950bfb0f","slug":"rat-l6-glucose-consumption","display_name":"Rat L6 myotube glucose consumption","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/mangiferin-research/24033319.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"9e8f13eba529ca6e56c33c3cee21d8fef473025e4bea72d81b375c96031ee84a\", \"start_char\": 0, \"end_char\": 1791, \"text_sha256\": \"9e8f13eba529ca6e56c33c3cee21d8fef473025e4bea72d81b375c96031ee84a\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Normal and insulin-resistant L6 myotube comparison","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Micromolar mangiferin or norathyriol, with or without 0.05 nM insulin","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Cell glucose consumption and phosphorylation assays; AMPK association alone does not prove direct binding or human glucose lowering.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Mangiferin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Rattus norvegicus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The parent compound and metabolite differed under insulin resistance.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mangiferin-p24033319] Mangiferin and its aglycone, norathyriol, improve glucose metabolism by activation of AMP-activated protein kinase. (2014). https://pubmed.ncbi.nlm.nih.gov/24033319/ DOI: 10.3109/13880209.2013.814691","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"L6 myotubes","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a0989602-807d-524a-a7d8-dd634fd70983","evidence_kind":"source_excerpt","locator":"Lines 418-429","start_line":418,"end_line":429,"excerpt":"### mangiferin-insulin-context\nIn insulin-resistant L6 cells, mangiferin increased glucose consumption only with insulin co-treatment; norathyriol worked with or without insulin.\nCondition category: normal\nnutrient_topic: Mangiferin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The parent compound and metabolite differed under insulin resistance.\norganism: Rattus norvegicus\ntissue_or_cell_type: L6 myotubes\nexperimental_model: Normal and insulin-resistant L6 myotube comparison\nlimitations: Cell glucose consumption and phosphorylation assays; AMPK association alone does not prove direct binding or human glucose lowering.\nexposure: Micromolar mangiferin or norathyriol, with or without 0.05 nM insulin\nevidence_span: {\"source_cache\": \"artifacts/mangiferin-research/24033319.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"9e8f13eba529ca6e56c33c3cee21d8fef473025e4bea72d81b375c96031ee84a\", \"start_char\": 0, \"end_char\": 1791, \"text_sha256\": \"9e8f13eba529ca6e56c33c3cee21d8fef473025e4bea72d81b375c96031ee84a\"}\n[mangiferin-p24033319] Mangiferin and its aglycone, norathyriol, improve glucose metabolism by activation of AMP-activated protein kinase. (2014). https://pubmed.ncbi.nlm.nih.gov/24033319/ DOI: 10.3109/13880209.2013.814691","model_system":"Normal and insulin-resistant L6 myotube comparison","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [mangiferin-p24033319] Mangiferin and its aglycone, norathyriol, improve glucose metabolism by activation of AMP-activated protein kinase. (2014). https://pubmed.ncbi.nlm.nih.gov/24033319/ DOI: 10.3109/13880209.2013.814691","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"267f942a-695a-5b62-a858-f71c06321ff5","stable_key":"import-475ea55a-65e9-51c3-a539-738a6a8f683f","title":"Mangiferin: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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