{"id":"dc37799a-274b-5494-8bd7-343cd8c58f20","stable_key":"ec174d5a-4903-5745-8646-df0e9d4265e8:fol-micronuclei-repletion-response","predicate":"supplementation_reduced_micronucleus_frequency","statement":"Elevated micronucleus frequencies associated with low folate were reduced following supplementation.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"1e870f60-1ee2-50dc-818f-c978bdc4166a","mechanism_event_label":"A separate marker of chromosome damage also improved.","subject":{"id":"d322bfef-5135-599f-82e6-0aa58748dc8b","slug":"folic-acid","display_name":"Folic acid","entity_type_key":"small_molecule"},"object":{"id":"7f4cf9b8-d2fb-5350-b7fb-1c33da39c2a5","slug":"erythrocyte-micronucleus-frequency","display_name":"Erythrocyte micronucleus frequency","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1e870f60-1ee2-50dc-818f-c978bdc4166a","stable_key":"ec174d5a-4903-5745-8646-df0e9d4265e8:fol-micronuclei-repletion-response-event","event_type":"observed_intervention","label":"A separate marker of chromosome damage also improved.","description":"Elevated micronucleus frequencies associated with low folate were reduced following supplementation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d322bfef-5135-599f-82e6-0aa58748dc8b","slug":"folic-acid","display_name":"Folic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7f4cf9b8-d2fb-5350-b7fb-1c33da39c2a5","slug":"erythrocyte-micronucleus-frequency","display_name":"Erythrocyte micronucleus frequency","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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blood DNA uracil and erythrocyte/reticulocyte micronuclei.\n[fol-blount1997] Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage (1997). https://pubmed.ncbi.nlm.nih.gov/9096386/ DOI: 10.1073/pnas.94.7.3290","model_system":"Selected splenectomized human volunteers: 22 at baseline, 19 supplementation completers; additional blood/marrow samples and Crohn case analyzed separately.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [fol-blount1997] Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage (1997). https://pubmed.ncbi.nlm.nih.gov/9096386/ DOI: 10.1073/pnas.94.7.3290","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"f4ce1a62-9582-5f7a-84f5-a23d0e1bfc68","stable_key":"import-ec174d5a-4903-5745-8646-df0e9d4265e8","title":"Folate and folic acid: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e564d43989ece1006c95cd0748e9af6fe369074599a2eebba0a99ebff864b0dd","revision_id":"76674a33-b2a1-5e41-b71b-44399038ff7c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}