{"id":"dc011738-2bea-574e-a758-16b474b4a4b6","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-ankaflavin-glycation-null","predicate":"does_not_inhibit_tested","statement":"Ankaflavin did not inhibit AGE generation in the reported cell-free experiment despite lower AGE endpoints in treated rats.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"0b5bfd7c-f5f8-54b9-8944-9996aff6b026","mechanism_event_label":"Direct chemical trapping and an organism-level effect are separate possibilities.","subject":{"id":"92939faa-84d1-52e8-a70f-deefd2486d52","slug":"ankaflavin","display_name":"Ankaflavin","entity_type_key":"small_molecule"},"object":{"id":"c8847919-231d-5d23-bc19-ee017e263dbe","slug":"ankaflavin-direct-age-assay","display_name":"Direct AGE-generation assay in the ankaflavin study","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"0b5bfd7c-f5f8-54b9-8944-9996aff6b026","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-ankaflavin-glycation-null-event","event_type":"observed_relationship","label":"Direct chemical trapping and an organism-level effect are separate possibilities.","description":"Ankaflavin did not inhibit AGE generation in the reported cell-free experiment despite lower AGE endpoints in treated rats.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"92939faa-84d1-52e8-a70f-deefd2486d52","slug":"ankaflavin","display_name":"Ankaflavin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c8847919-231d-5d23-bc19-ee017e263dbe","slug":"ankaflavin-direct-age-assay","display_name":"Direct AGE-generation assay in the ankaflavin study","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"In-vitro glycation assay in the 2012 study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Assay conditions differ from later pigment-rich mixture experiments; no automatic contradiction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"red-yeast-rice","display_name":"Red yeast rice","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Direct chemical trapping and an organism-level effect are separate possibilities.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[23022408] Ankaflavin: a natural novel PPARγ agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo. · 2012 · https://pubmed.ncbi.nlm.nih.gov/23022408/ · DOI 10.1016/j.freeradbiomed.2012.09.025","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4b59111d-9000-5425-9be4-3cd8151ffb6c","evidence_kind":"source_excerpt","locator":"Lines 268-274","start_line":268,"end_line":274,"excerpt":"## red-yeast-rice-ankaflavin-glycation-null\nDirect chemical trapping and an organism-level effect are separate possibilities.\nAnkaflavin did not inhibit AGE generation in the reported cell-free experiment despite lower AGE endpoints in treated rats.\nModel: In-vitro glycation assay in the 2012 study.\nLimitations: Assay conditions differ from later pigment-rich mixture experiments; no automatic contradiction.\nEvidence access: Primary abstract\n[23022408] Ankaflavin: a natural novel PPARγ agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo. · 2012 · https://pubmed.ncbi.nlm.nih.gov/23022408/ · DOI 10.1016/j.freeradbiomed.2012.09.025","model_system":"In-vitro glycation assay in the 2012 study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"261a12bc-3d00-52a4-a5ec-70e174390596","stable_key":"import-4910e17b-aaec-52cd-b9e5-caca85d817ee","title":"Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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