{"id":"dbf97416-371c-55dd-90ce-04c3e83ed999","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-methyl-amination","predicate":"yields_aminated_metabolite","statement":"LC-MS analysis supported amination of Mono-O-methylated myricetin; positional isomer unresolved in myricetin-treated mice.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d5a3d545-5e92-54a2-9bc1-ceb15b32e728","mechanism_event_label":"Downstream products can undergo further chemistry.","subject":{"id":"a0f28aad-bf70-57cc-be0c-ea3f7010fad9","slug":"mono-methylated-myricetin","display_name":"Mono-O-methylated myricetin; positional isomer unresolved","entity_type_key":"small_molecule"},"object":{"id":"bbffc137-6901-51d0-a2a0-de2b29545199","slug":"aminated-mono-methyl-myricetin","display_name":"Aminated mono-O-methylated myricetin; positional isomer unresolved","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"d5a3d545-5e92-54a2-9bc1-ceb15b32e728","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-methyl-amination-event","event_type":"observed_relationship","label":"Downstream products can undergo further chemistry.","description":"LC-MS analysis supported amination of Mono-O-methylated myricetin; positional isomer unresolved in myricetin-treated mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a0f28aad-bf70-57cc-be0c-ea3f7010fad9","slug":"mono-methylated-myricetin","display_name":"Mono-O-methylated myricetin; positional isomer unresolved","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"bbffc137-6901-51d0-a2a0-de2b29545199","slug":"aminated-mono-methyl-myricetin","display_name":"Aminated mono-O-methylated myricetin; positional isomer unresolved","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"1374ec24-1a5b-552b-982f-51f9082f4187","slug":"ammonia","display_name":"Ammonia","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse fecal/plasma metabolite analysis after oral dosing.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Structural certainty differs from the NMR-confirmed parent amination product; no human flux measured.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Myricetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Downstream products can undergo further chemistry.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Biotransformation of Myricetin: A Novel Metabolic Pathway to Produce Aminated Products in Mice. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31087612/ · DOI 10.1002/mnfr.201900203","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"1597b742-4b3e-559c-a45b-6bfea1f9816e","evidence_kind":"source_excerpt","locator":"Lines 84-90","start_line":84,"end_line":90,"excerpt":"## myricetin-methyl-amination\nDownstream products can undergo further chemistry.\nLC-MS analysis supported amination of Mono-O-methylated myricetin; positional isomer unresolved in myricetin-treated mice.\nModel: Mouse fecal/plasma metabolite analysis after oral dosing.\nLimitations: Structural certainty differs from the NMR-confirmed parent amination product; no human flux measured.\nEvidence access: Primary abstract\nBiotransformation of Myricetin: A Novel Metabolic Pathway to Produce Aminated Products in Mice. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31087612/ · DOI 10.1002/mnfr.201900203","model_system":"Mouse fecal/plasma metabolite analysis after oral dosing.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"58045cd9-3b27-5469-bb4b-e1c6a9bdca34","stable_key":"import-8182578e-8d21-598e-a3cb-e62d480d2251","title":"Myricetin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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