{"id":"dbf1b9fd-5fd3-5b1a-b5f5-067e2521d7c1","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:phospho1-loss-reduces-dentin-mineralization","predicate":"supports","statement":"Phospho1-null mouse incisors were hypomineralized, with a further defect after loss of one Alpl allele.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"d6144218-6124-5268-8d63-4746da956057","mechanism_event_label":"Tooth dentin depends on mineral-processing enzymes as well as mineral supply.","subject":{"id":"bb7ed19e-2f65-5951-8963-40d6b3249b71","slug":"phospho1","display_name":"Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1","entity_type_key":"protein"},"object":{"id":"0eb3cb55-3b0d-5d96-bd48-b1ac5f086126","slug":"dentin-mineralization","display_name":"Dentin mineralization","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d6144218-6124-5268-8d63-4746da956057","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:phospho1-loss-reduces-dentin-mineralization-event","event_type":"biochemical_relationship","label":"Tooth dentin depends on mineral-processing enzymes as well as mineral supply.","description":"Phospho1-null mouse incisors were hypomineralized, with a further defect after loss of one Alpl allele.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"bb7ed19e-2f65-5951-8963-40d6b3249b71","slug":"phospho1","display_name":"Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1","entity_type_key":"protein"},"role":"deleted_enzyme","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3148c377-9b4c-56ca-bc36-081bf1905d57","slug":"alpl","display_name":"Tissue-nonspecific alkaline phosphatase ALPL / TNAP","entity_type_key":"protein"},"role":"genetic_modifier","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"0da3fbd1-7438-5d0a-954d-f059bd3d22a9","slug":"matrix-vesicle","display_name":"Mineralizing matrix vesicle","entity_type_key":"organelle"},"role":"mineralization_compartment","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"0eb3cb55-3b0d-5d96-bd48-b1ac5f086126","slug":"dentin-mineralization","display_name":"Dentin mineralization","entity_type_key":"cellular_process"},"role":"outcome","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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