{"id":"db9bcb30-b387-508e-a71e-4a31213b2437","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-salt-glycemic-anion-boundary","predicate":"modulates","statement":"Both potassium salts improved beta-cell-function estimates; only citrate improved insulin-sensitivity estimates in this small normokalemic pilot.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"df440650-2366-5bab-9163-418b291deffc","mechanism_event_label":"The accompanying anion changed the observed metabolic response.","subject":{"id":"3b29ab32-ccaf-5805-9eb4-894dd7c30a6b","slug":"potassium-citrate","display_name":"Potassium citrate","entity_type_key":"chemical_species"},"object":{"id":"63223a9d-b872-57dd-b4b9-2085d2db023f","slug":"homa-insulin-resistance","display_name":"HOMA-IR estimate of insulin resistance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"df440650-2366-5bab-9163-418b291deffc","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-salt-glycemic-anion-boundary-event","event_type":"observed_intervention","label":"The accompanying anion changed the observed metabolic response.","description":"Both potassium salts improved beta-cell-function estimates; 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unverified.","entity":null}],"evidence":[{"id":"b932e39c-8af1-58e2-8c2c-d7ee4114d58c","evidence_kind":"source_excerpt","locator":"Lines 946-956","start_line":946,"end_line":956,"excerpt":"### k-salt-glycemic-anion-boundary\nBoth potassium salts improved beta-cell-function estimates; only citrate improved insulin-sensitivity estimates in this small normokalemic pilot.\nCondition category: biomarker_context\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The accompanying anion changed the observed metabolic response.\norganism: Human\ntissue_or_cell_type: Systemic glucose regulation\nexperimental_model: Eleven non-acidotic normokalemic adults, 7 men/4 women, ages 47-63; double-blind placebo-controlled KCl/K-citrate 90 mEq/day, two weeks each.\nlimitations: Eleven subjects, short duration and surrogate estimates; no established molecular pathway or prevention effect.\ncross_nutrient: Potassium and accompanying alkali cannot be treated as an identical intervention.\n[conen-2016-pilot] Effects of potassium citrate or potassium chloride in patients with combined glucose intolerance: A placebo-controlled pilot study (2016). https://www.sciencedirect.com/science/article/abs/pii/S105687271630054X DOI: 10.1016/j.jdiacomp.2016.03.017","model_system":"Eleven non-acidotic normokalemic adults, 7 men/4 women, ages 47-63; 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