{"id":"db6581b3-cee1-58cc-ae79-17863ea605a1","stable_key":"335be270-ea4a-5c8e-ad04-964fd22a439e:vanadium-duck-redox-axis","predicate":"associated_with_suppression","statement":"Dietary vanadium overexposure in ducks was associated with lower NADH/FSP1/CoQ10-axis measures and increased hepatic lipid peroxidation and Fe2+ accumulation.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"4313cbc7-ad41-55f1-b00b-363f2b870104","mechanism_event_label":"An animal toxicity study links the exposure to a lipid-defense pathway.","subject":{"id":"aa53e24f-9ce4-52cf-80cc-4575c9b10b7a","slug":"ammonium-metavanadate","display_name":"Ammonium metavanadate","entity_type_key":"chemical_species"},"object":{"id":"d91c0973-b87e-5ce6-8a75-4439b8ba66cb","slug":"duck-aifm2","display_name":"Duck FSP1 / AIFM2","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"4313cbc7-ad41-55f1-b00b-363f2b870104","stable_key":"335be270-ea4a-5c8e-ad04-964fd22a439e:vanadium-duck-redox-axis-event","event_type":"observed_relationship","label":"An animal toxicity study links the exposure to a lipid-defense pathway.","description":"Dietary vanadium overexposure in ducks was associated with lower NADH/FSP1/CoQ10-axis measures and increased hepatic lipid peroxidation and Fe2+ accumulation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"aa53e24f-9ce4-52cf-80cc-4575c9b10b7a","slug":"ammonium-metavanadate","display_name":"Ammonium metavanadate","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d91c0973-b87e-5ce6-8a75-4439b8ba66cb","slug":"duck-aifm2","display_name":"Duck FSP1 / AIFM2","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c5cbad45-22c6-594b-ab6b-71880dab1b24","slug":"vanadium","display_name":"Vanadium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9fbf2e03-16a9-5ca7-965c-0bfc07ca24da","slug":"nadh","display_name":"NADH","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"f1bcf0ac-3578-5afa-97d7-ef3551b657c5","slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"a4a2a3cf-c487-52f1-9ab2-0c2babb1161a","slug":"duck-gpx4","display_name":"Duck glutathione peroxidase 4 / GPX4","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""},{"entity":{"id":"59d6d1cd-df32-5b58-b950-3188bc7b95d6","slug":"iron-ii","display_name":"Ferrous iron","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":6,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Ammonium metavanadate diets reported as 30 or 45 mg V/kg feed; 42-day duck study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Observational pathway measurements after exposure, not direct enzyme inhibition or a human ferroptosis mechanism. Methods inconsistently say three and four groups while listing control plus two exposure groups.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vanadium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vanadium","display_name":"Vanadium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"An animal toxicity study links the exposure to a lipid-defense pathway.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Dual-pathway mechanism of vanadium-induced hepatotoxicity in ducks: Synergistic crosstalk between glucose homeostasis disruption and NADH/FSP1/COQ10 axis-driven ferroptosis. · 2026 · https://pubmed.ncbi.nlm.nih.gov/41362732/ · DOI 10.7150/ijbs.123482","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"40806242-0db1-54a3-8b6b-56f6b7c66f20","evidence_kind":"source_excerpt","locator":"Lines 358-364","start_line":358,"end_line":364,"excerpt":"## vanadium-duck-redox-axis\nAn animal toxicity study links the exposure to a lipid-defense pathway.\nDietary vanadium overexposure in ducks was associated with lower NADH/FSP1/CoQ10-axis measures and increased hepatic lipid peroxidation and Fe2+ accumulation.\nModel: Ammonium metavanadate diets reported as 30 or 45 mg V/kg feed; 42-day duck study.\nLimitations: Observational pathway measurements after exposure, not direct enzyme inhibition or a human ferroptosis mechanism. Methods inconsistently say three and four groups while listing control plus two exposure groups.\nEvidence access: Primary full text\nDual-pathway mechanism of vanadium-induced hepatotoxicity in ducks: Synergistic crosstalk between glucose homeostasis disruption and NADH/FSP1/COQ10 axis-driven ferroptosis. · 2026 · https://pubmed.ncbi.nlm.nih.gov/41362732/ · DOI 10.7150/ijbs.123482","model_system":"Ammonium metavanadate diets reported as 30 or 45 mg V/kg feed; 42-day duck study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e4d5d0ba-529b-540f-96ed-e719d116ccfd","stable_key":"import-335be270-ea4a-5c8e-ad04-964fd22a439e","title":"Vanadium: speciation, phosphate-sensitive enzymes and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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