{"id":"db1b73d3-75c7-5ad0-a025-4f8eecb0b805","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-microbial-sulfide","predicate":"inhibits","statement":"Taurine-supported microbiota increased sulfide production, which inhibited respiration important for invasion by the tested enteric pathogens; sulfide sequestration promoted invasion.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d4e70036-956a-5938-a7b1-9da10ac60c58","mechanism_event_label":"The microbial product blocked a pathway that pathogens needed.","subject":{"id":"70cc3ced-8adc-5e76-9750-e1415683455b","slug":"hydrogen-sulfide","display_name":"Hydrogen sulfide / H2S","entity_type_key":"small_molecule"},"object":{"id":"fcd83174-7613-5570-9bc9-135d902d6496","slug":"microbial-respiratory-pathogen-growth","display_name":"Respiration-dependent growth of tested enteric pathogens","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d4e70036-956a-5938-a7b1-9da10ac60c58","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-microbial-sulfide-event","event_type":"observed_relationship","label":"The microbial product blocked a pathway that pathogens needed.","description":"Taurine-supported microbiota increased sulfide production, which inhibited respiration important for invasion by the tested enteric pathogens; 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molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The microbial product blocked a pathway that pathogens needed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Infection trains the host for microbiota-enhanced resistance to pathogens. · 2021 · https://pubmed.ncbi.nlm.nih.gov/33453153/ · DOI 10.1016/j.cell.2020.12.011","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0b572dff-2a96-5593-b02d-295e4ddddf88","evidence_kind":"source_excerpt","locator":"Lines 353-359","start_line":353,"end_line":359,"excerpt":"## taurine-microbial-sulfide\nThe microbial product blocked a pathway that pathogens needed.\nTaurine-supported microbiota increased sulfide production, which inhibited respiration important for invasion by the tested enteric pathogens; sulfide sequestration promoted invasion.\nModel: Mouse colonization-resistance study with microbial and sulfide interventions.\nLimitations: Local microbial sulfide, circulating host sulfide and systemic sulfide toxicity are distinct exposures.\nEvidence access: Primary abstract\nInfection trains the host for microbiota-enhanced resistance to pathogens. · 2021 · https://pubmed.ncbi.nlm.nih.gov/33453153/ · DOI 10.1016/j.cell.2020.12.011","model_system":"Mouse colonization-resistance study with microbial and sulfide interventions.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc8d9ab8-fdf9-5107-877c-336cf8005097","stable_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c6cb77619a374d9b1b04830032fdd3b33d269d160df5baba3778fad5adf57db5","revision_id":"cc45c491-cc6a-5426-ab72-d7c6d26c3614","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}