{"id":"db028873-09db-5bed-b22c-d8d7f5df7c91","stable_key":"475ea55a-65e9-51c3-a539-738a6a8f683f:mangiferin-enterocloster","predicate":"decreases","statement":"Norathyriol suppressed the urate-consuming species Enterocloster bolteae in culture.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e5bd2a3e-90df-52c0-bbd4-eca91a866260","mechanism_event_label":"The affected community includes microbes that consume urate.","subject":{"id":"d0f7f42a-ac45-5144-9ea5-a7586896cc6e","slug":"norathyriol","display_name":"Norathyriol","entity_type_key":"small_molecule"},"object":{"id":"6ae71a62-cbc4-5f3f-a212-d86df021837f","slug":"enterocloster-bolteae-culture-abundance","display_name":"Enterocloster bolteae abundance in fecal cultures","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e5bd2a3e-90df-52c0-bbd4-eca91a866260","stable_key":"475ea55a-65e9-51c3-a539-738a6a8f683f:mangiferin-enterocloster-event","event_type":"biochemical_relationship","label":"The affected community includes microbes that consume urate.","description":"Norathyriol suppressed the urate-consuming species Enterocloster bolteae in culture.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d0f7f42a-ac45-5144-9ea5-a7586896cc6e","slug":"norathyriol","display_name":"Norathyriol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6ae71a62-cbc4-5f3f-a212-d86df021837f","slug":"enterocloster-bolteae-culture-abundance","display_name":"Enterocloster bolteae abundance in fecal cultures","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/mangiferin-research/40401774.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"56539abd79e79a7968a5ec040d9fff33a864b228236cfecba1c7e0ccd3eae380\", \"start_char\": 0, \"end_char\": 1390, \"text_sha256\": \"56539abd79e79a7968a5ec040d9fff33a864b228236cfecba1c7e0ccd3eae380\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Ex vivo human fecal fermentation and metagenomic profiling","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Mangiferin or norathyriol 500 micromolar in culture; not participant supplementation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Community findings do not establish health benefit or harm in people; candidate converter taxa were associations, not isolated causal proof.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Mangiferin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human-derived microbial communities","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The affected community includes microbes that consume urate.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mangiferin-p40401774] Gut microbiota-mediated conversion of mangiferin to norathyriol alters short chain fatty acid and urate metabolism. (2025). https://pubmed.ncbi.nlm.nih.gov/40401774/ DOI: 10.1080/19490976.2025.2508422","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Fecal cultures","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0420186c-a82f-5632-806b-80f8f2f3b285","evidence_kind":"source_excerpt","locator":"Lines 184-195","start_line":184,"end_line":195,"excerpt":"### mangiferin-enterocloster\nNorathyriol suppressed the urate-consuming species Enterocloster bolteae in culture.\nCondition category: normal\nnutrient_topic: Mangiferin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The affected community includes microbes that consume urate.\norganism: Human-derived microbial communities\ntissue_or_cell_type: Fecal cultures\nexperimental_model: Ex vivo human fecal fermentation and metagenomic profiling\nlimitations: Community findings do not establish health benefit or harm in people; candidate converter taxa were associations, not isolated causal proof.\nexposure: Mangiferin or norathyriol 500 micromolar in culture; not participant supplementation\nevidence_span: {\"source_cache\": \"artifacts/mangiferin-research/40401774.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"56539abd79e79a7968a5ec040d9fff33a864b228236cfecba1c7e0ccd3eae380\", \"start_char\": 0, \"end_char\": 1390, \"text_sha256\": \"56539abd79e79a7968a5ec040d9fff33a864b228236cfecba1c7e0ccd3eae380\"}\n[mangiferin-p40401774] Gut microbiota-mediated conversion of mangiferin to norathyriol alters short chain fatty acid and urate metabolism. 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