{"id":"dacb9152-22c6-50d8-8365-53912d251ccd","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-polyploidy","predicate":"increases","statement":"Fisetin produced numerical chromosome abnormalities in human TK6 cells, with hyperdiploidy/polyploidy most evident after recovery from a cell-cycle delay.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"e2923aea-4d4a-5391-9ce8-49dfc0750f20","mechanism_event_label":"Timing affected when chromosome abnormalities were detected.","subject":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"object":{"id":"b079232b-09ff-5bc8-bc5c-3bdfb28355a1","slug":"human-tk6-fisetin-polyploidy","display_name":"Polyploidy and hyperdiploidy in fisetin-treated human TK6 cells","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e2923aea-4d4a-5391-9ce8-49dfc0750f20","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-polyploidy-event","event_type":"observed_relationship","label":"Timing affected when chromosome abnormalities were detected.","description":"Fisetin produced numerical chromosome abnormalities in human TK6 cells, with hyperdiploidy/polyploidy most evident after recovery from a cell-cycle delay.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b079232b-09ff-5bc8-bc5c-3bdfb28355a1","slug":"human-tk6-fisetin-polyploidy","display_name":"Polyploidy and hyperdiploidy in fisetin-treated human TK6 cells","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Comparison with two Aurora kinase inhibitors.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Phenotypic similarity does not establish exclusive Aurora B mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fisetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Timing affected when chromosome abnormalities were detected.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"A comparative study of the aneugenic and polyploidy-inducing effects of fisetin and two model Aurora kinase inhibitors. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24680981/ · DOI 10.1016/j.mrgentox.2014.03.004","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6e772521-029d-502b-a281-284cf566ffdb","evidence_kind":"source_excerpt","locator":"Lines 496-502","start_line":496,"end_line":502,"excerpt":"## fisetin-polyploidy\nTiming affected when chromosome abnormalities were detected.\nFisetin produced numerical chromosome abnormalities in human TK6 cells, with hyperdiploidy/polyploidy most evident after recovery from a cell-cycle delay.\nModel: Comparison with two Aurora kinase inhibitors.\nLimitations: Phenotypic similarity does not establish exclusive Aurora B mediation.\nEvidence access: Primary abstract\nA comparative study of the aneugenic and polyploidy-inducing effects of fisetin and two model Aurora kinase inhibitors. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24680981/ · DOI 10.1016/j.mrgentox.2014.03.004","model_system":"Comparison with two Aurora kinase inhibitors.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1108bfff-6504-5152-a51f-ff3d7c27c282","stable_key":"import-74ef5bba-ee14-531c-b1bf-d1f297c56bb6","title":"Fisetin: metabolism, cell-state responses and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c30e0764cd34bd062cfcbfaf32357ef29dfda30e7d4153c545178140f5054e09","revision_id":"40ff52c0-f4b9-5820-8abb-ff002c6364a4","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}