{"id":"dab0742f-e713-55a3-8408-cebf800a4cb0","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-mci-nfl","predicate":"associated_with_stabilization","statement":"Plasma neurofilament light remained stable in the ergothioneine arm of the 19-person MCI pilot while increasing in placebo recipients.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"702160b7-2d44-559d-9ddc-3de515afe811","mechanism_event_label":"A blood injury marker accompanied the learning result.","subject":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"object":{"id":"244d93a3-af27-5d41-ae9c-d147fdffe2da","slug":"human-ergo-pilot-neurofilament-light","display_name":"Human plasma neurofilament-light response in ergothioneine pilot","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"702160b7-2d44-559d-9ddc-3de515afe811","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-mci-nfl-event","event_type":"observed_relationship","label":"A blood injury marker accompanied the learning result.","description":"Plasma neurofilament light remained stable in the ergothioneine arm of the 19-person MCI pilot while increasing in placebo recipients.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"244d93a3-af27-5d41-ae9c-d147fdffe2da","slug":"human-ergo-pilot-neurofilament-light","display_name":"Human plasma neurofilament-light response in ergothioneine pilot","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same one-year trial as the verbal-learning record.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not an independent replication or proof of reduced neurodegeneration.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A blood injury marker accompanied the learning result.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Investigating the efficacy of ergothioneine to delay cognitive decline in mild cognitively impaired subjects: A pilot study. · 2024 · https://pubmed.ncbi.nlm.nih.gov/39544014/ · DOI 10.1177/13872877241291253","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c3d378ce-c4da-526d-bc73-e05770559132","evidence_kind":"source_excerpt","locator":"Lines 504-510","start_line":504,"end_line":510,"excerpt":"## ergothioneine-mci-nfl\nA blood injury marker accompanied the learning result.\nPlasma neurofilament light remained stable in the ergothioneine arm of the 19-person MCI pilot while increasing in placebo recipients.\nModel: Same one-year trial as the verbal-learning record.\nLimitations: Not an independent replication or proof of reduced neurodegeneration.\nEvidence access: Primary abstract\nInvestigating the efficacy of ergothioneine to delay cognitive decline in mild cognitively impaired subjects: A pilot study. · 2024 · https://pubmed.ncbi.nlm.nih.gov/39544014/ · DOI 10.1177/13872877241291253","model_system":"Same one-year trial as the verbal-learning record.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2f037d98-f3d0-5dbe-80d8-90b738f130d6","stable_key":"import-59b18080-c560-563d-abc5-bac4ee82a27c","title":"Ergothioneine: transport, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b6def8119f03cfabeec2fb55ba924340dc612e1dd42f05404201fa2b7ced5259","revision_id":"f88c38e6-ffb5-5a68-83ca-4610ca2c2df4","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}