{"id":"daada143-1a12-5429-b459-9f575b6827da","stable_key":"ff370329-68a3-573d-96ee-597de78a3967:api-chamomile-allergy","predicate":"reported_relationship","statement":"The report described anaphylaxis after chamomile tea in an atopic child, with IgE cross-reactivity involving plant/pollen preparations.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"72004eb2-e104-5cd1-8d93-23887ed877a3","mechanism_event_label":"The report described anaphylaxis after chamomile tea in an atopic child, with IgE cross-reactivity involving plant/pollen preparations.","subject":{"id":"b48e9908-0eb0-5e53-b8b1-e38765a0c2d5","slug":"chamomile-allergy-case-1989","display_name":"Chamomile tea in the 1989 allergy case","entity_type_key":"botanical"},"object":{"id":"f479eca8-fd30-5bfa-9bee-840efcb90bb7","slug":"api-chamomile-allergic-response","display_name":"IgE-associated reaction to chamomile in the 1989 case","entity_type_key":"botanical"},"evidence_count":1,"mechanism_event":{"id":"72004eb2-e104-5cd1-8d93-23887ed877a3","stable_key":"ff370329-68a3-573d-96ee-597de78a3967:api-chamomile-allergy-event","event_type":"experimental_observation","label":"The report described anaphylaxis after chamomile tea in an atopic child, with IgE cross-reactivity involving plant/pollen preparations.","description":"### api-chamomile-allergy\n\nThe report described anaphylaxis after chamomile tea in an atopic child, with IgE cross-reactivity involving plant/pollen preparations.\nThis does not identify purified apigenin as the allergen; the preparation remains the actor.\nModel and exposure: Eight-year-old boy; case report and allergy testing.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Anaphylactic reaction after the ingestion of chamomile tea: a study of cross-reactivity with other composite pollens. | 1989 | https://pubmed.ncbi.nlm.nih.gov/2674263/ | https://doi.org/10.1016/0091-6749(89)90420-x | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b48e9908-0eb0-5e53-b8b1-e38765a0c2d5","slug":"chamomile-allergy-case-1989","display_name":"Chamomile tea in the 1989 allergy case","entity_type_key":"botanical"},"role":"recorded factor","stoichiometry":null,"state_label":"as reported","sequence_order":0,"notes":""},{"entity":{"id":"f479eca8-fd30-5bfa-9bee-840efcb90bb7","slug":"api-chamomile-allergic-response","display_name":"IgE-associated reaction to chamomile in the 1989 case","entity_type_key":"botanical"},"role":"measured outcome","stoichiometry":null,"state_label":"not_reported","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Eight-year-old boy; case report and allergy testing.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Recorded from source with stated access limits; ungraded, not independent replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Apigenin collection; exact intervention and molecular form govern interpretation.","comparator":null,"unit":null,"notes":"","entity":{"slug":"apigenin","display_name":"Apigenin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The report described anaphylaxis after chamomile tea in an atopic child, with IgE cross-reactivity involving plant/pollen preparations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Anaphylactic reaction after the ingestion of chamomile tea: a study of cross-reactivity with other composite pollens. | https://pubmed.ncbi.nlm.nih.gov/2674263/ | https://doi.org/10.1016/0091-6749(89)90420-x","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference api-chamomile-allergy; This does not identify purified apigenin as the allergen; the preparation remains the actor.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8aec9128-268f-505a-a67f-99ada55bad03","evidence_kind":"source_excerpt","locator":"Lines 944-950","start_line":944,"end_line":950,"excerpt":"### api-chamomile-allergy\n\nThe report described anaphylaxis after chamomile tea in an atopic child, with IgE cross-reactivity involving plant/pollen preparations.\nThis does not identify purified apigenin as the allergen; the preparation remains the actor.\nModel and exposure: Eight-year-old boy; case report and allergy testing.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Anaphylactic reaction after the ingestion of chamomile tea: a study of cross-reactivity with other composite pollens. | 1989 | https://pubmed.ncbi.nlm.nih.gov/2674263/ | https://doi.org/10.1016/0091-6749(89)90420-x | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","model_system":"Eight-year-old boy; case report and allergy testing.","directness":"reported_statement","verification_status":"source_recorded","notes":"Original paraphrase in the retained reviewed reference, not a verbatim primary-paper quotation. Access level is explicit.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"54eac90b-add1-5f56-9036-d900307c5697","stable_key":"import-ff370329-68a3-573d-96ee-597de78a3967","title":"Apigenin: detailed mechanisms of action (reviewed 10 October 2026)","document_type":"imported_text","citation_label":"AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed.","file_path":"","sha256":"ede6e5c6b91d66b66844f2ff667a7f8303d9ac1281f15dc09db703f7de4da942","revision_id":"b41a39a2-0197-549c-97a5-1765e6696931","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}