{"id":"da712820-e7e9-53c2-863c-d97d3b651969","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-hypopp-gating-pore","predicate":"permits","statement":"R528H mouse fibers displayed anomalous inward current at resting potentials, supporting a voltage-sensor leak mechanism.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"b297cb83-c518-54d7-abba-baa18e11f2d7","mechanism_event_label":"An inherited calcium-channel variant added an abnormal leak.","subject":{"id":"4466c8a4-6a5a-503e-83df-803513f953e1","slug":"cacna1s-r528h","display_name":"CaV1.1 R528H variant","entity_type_key":"protein_state"},"object":{"id":"85a5c6ff-8395-5514-8967-48c5e325cb50","slug":"gating-pore-current","display_name":"Voltage-sensor gating-pore current","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b297cb83-c518-54d7-abba-baa18e11f2d7","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-hypopp-gating-pore-event","event_type":"biochemical_relationship","label":"An inherited calcium-channel variant added an abnormal leak.","description":"R528H mouse fibers displayed anomalous inward current at resting potentials, supporting a voltage-sensor leak mechanism.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ddcd2d1b-bae6-5ef8-ab69-19dd920ace19","slug":"cacna1s","display_name":"CaV1.1 alpha-1S / CACNA1S","entity_type_key":"protein"},"role":"wild-type identity","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5dd31e52-f51e-51f3-880e-240abcc0ab1d","slug":"potassium-ion","display_name":"Potassium ion","entity_type_key":"ion"},"role":"contextual extracellular ion","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"4466c8a4-6a5a-503e-83df-803513f953e1","slug":"cacna1s-r528h","display_name":"CaV1.1 R528H variant","entity_type_key":"protein_state"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"85a5c6ff-8395-5514-8967-48c5e325cb50","slug":"gating-pore-current","display_name":"Voltage-sensor gating-pore current","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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Study references: [wu-2012-hypopp] A calcium channel mutant mouse model of hypokalemic periodic paralysis (2012). https://pmc.ncbi.nlm.nih.gov/articles/PMC3533564/ DOI: 10.1172/JCI66091","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"241226ee-6b7d-5cc7-9781-e6beb8ee1982","stable_key":"import-5102beb6-9f61-500e-af10-9ac63649e0b7","title":"Potassium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a8f89f8d84b48c0f93048dfc45f7f57a67dd9a7249968a096a14aeb03d8b7a52","revision_id":"de4ec6f4-58a1-537b-8169-97b783898df1","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}