{"id":"da39b50a-6cc8-5dda-a0c9-e69fc1ff37a7","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-controlled-feeding-regulatory-hormones","predicate":"supplementation_changes","statement":"Potassium increased aldosterone, renin and copeptin in the post-hoc hormone analysis while blood pressure fell.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d3bfdd0a-7760-5ca8-a604-447a50eb6eec","mechanism_event_label":"A hormone response can accompany a pressure reduction rather than imply the opposite outcome.","subject":{"id":"87435e1d-e1cd-57da-984b-203b2f5f29a4","slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"},"object":{"id":"247d380e-2ac5-53ad-8d50-fc8f96c6c12b","slug":"plasma-aldosterone-concentration","display_name":"Plasma aldosterone concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d3bfdd0a-7760-5ca8-a604-447a50eb6eec","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-controlled-feeding-regulatory-hormones-event","event_type":"observed_intervention","label":"A hormone response can accompany a pressure reduction rather than imply the opposite outcome.","description":"Potassium increased aldosterone, renin and copeptin in the post-hoc hormone analysis while blood pressure fell.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4ed6f3e2-76e5-577a-b3bb-64703cf550fa","slug":"aldosterone","display_name":"Aldosterone","entity_type_key":"small_molecule"},"role":"measured_hormone","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e952f1ac-eecd-5b97-84be-dda3b5cad00e","slug":"renin","display_name":"Renin","entity_type_key":"protein"},"role":"measured_hormone","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"31c01f4c-6f8d-5c08-afad-c6fcec729608","slug":"plasma-copeptin-concentration","display_name":"Plasma copeptin concentration","entity_type_key":"cellular_process"},"role":"vasopressin_surrogate","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"87435e1d-e1cd-57da-984b-203b2f5f29a4","slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"247d380e-2ac5-53ad-8d50-fc8f96c6c12b","slug":"plasma-aldosterone-concentration","display_name":"Plasma aldosterone concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Potassium -> endocrine regulation; sodium/volume context retained.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"35 participants from the same feeding trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Post-hoc circulating markers do not identify receptor signaling or a universal endocrine response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A hormone response can accompany a pressure reduction rather than imply the opposite outcome.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[k-gijsbers2016-hormones] Effects of potassium supplementation on markers of osmoregulation and volume regulation: results of a fully controlled dietary intervention study (2016). https://pubmed.ncbi.nlm.nih.gov/26599222/ DOI: 10.1097/hjh.0000000000000786","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"40f44c23-2aac-59d3-8136-ba10d5a18f49","evidence_kind":"source_excerpt","locator":"Lines 1568-1578","start_line":1568,"end_line":1578,"excerpt":"### k-controlled-feeding-regulatory-hormones\nPotassium increased aldosterone, renin and copeptin in the post-hoc hormone analysis while blood pressure fell.\nCondition category: normal\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A hormone response can accompany a pressure reduction rather than imply the opposite outcome.\norganism: Homo sapiens\ntissue_or_cell_type: Plasma\nexperimental_model: 35 participants from the same feeding trial.\nlimitations: Post-hoc circulating markers do not identify receptor signaling or a universal endocrine response.\ncross_nutrient: Potassium -> endocrine regulation; sodium/volume context retained.\n[k-gijsbers2016-hormones] Effects of potassium supplementation on markers of osmoregulation and volume regulation: results of a fully controlled dietary intervention study (2016). https://pubmed.ncbi.nlm.nih.gov/26599222/ DOI: 10.1097/hjh.0000000000000786","model_system":"35 participants from the same feeding trial.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [k-gijsbers2016-hormones] Effects of potassium supplementation on markers of osmoregulation and volume regulation: results of a fully controlled dietary intervention study (2016). https://pubmed.ncbi.nlm.nih.gov/26599222/ DOI: 10.1097/hjh.0000000000000786","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"241226ee-6b7d-5cc7-9781-e6beb8ee1982","stable_key":"import-5102beb6-9f61-500e-af10-9ac63649e0b7","title":"Potassium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a8f89f8d84b48c0f93048dfc45f7f57a67dd9a7249968a096a14aeb03d8b7a52","revision_id":"de4ec6f4-58a1-537b-8169-97b783898df1","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}