{"id":"da26de1f-e978-55e2-acdc-38cc1491ae1b","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-microbiota-sex","predicate":"changes","statement":"Astaxanthin altered gut microbial composition in male and female mice, but reported glucose/inflammatory associations were observed in males; male knockout mice showed greater Akkermansia abundance than fed wild types.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d1293947-83ad-5580-ba3c-07cf9735af24","mechanism_event_label":"Microbial and metabolic responses depended on sex and host genotype.","subject":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"object":{"id":"33aa1eb3-3c47-54d7-9815-a2315981d33e","slug":"mouse-astaxanthin-microbiota","display_name":"Mouse microbiota response to astaxanthin","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d1293947-83ad-5580-ba3c-07cf9735af24","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-microbiota-sex-event","event_type":"observed_relationship","label":"Microbial and metabolic responses depended on sex and host genotype.","description":"Astaxanthin altered gut microbial composition in male and female mice, but reported glucose/inflammatory associations were observed in males; 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molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Microbial and metabolic responses depended on sex and host genotype.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Astaxanthin-Shifted Gut Microbiota Is Associated with Inflammation and Metabolic Homeostasis in Mice. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32810865/ · DOI 10.1093/jn/nxaa222","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8e85d56e-af10-5ebc-bf60-60c06ef7a4db","evidence_kind":"source_excerpt","locator":"Lines 94-100","start_line":94,"end_line":100,"excerpt":"## astaxanthin-microbiota-sex\nMicrobial and metabolic responses depended on sex and host genotype.\nAstaxanthin altered gut microbial composition in male and female mice, but reported glucose/inflammatory associations were observed in males; male knockout mice showed greater Akkermansia abundance than fed wild types.\nModel: Same wild-type/Bco2-knockout feeding experiment.\nLimitations: Correlated changes in microbes, GLP-1 and inflammation do not prove microbial mediation.\nEvidence access: Primary abstract\nAstaxanthin-Shifted Gut Microbiota Is Associated with Inflammation and Metabolic Homeostasis in Mice. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32810865/ · DOI 10.1093/jn/nxaa222","model_system":"Same wild-type/Bco2-knockout feeding experiment.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4fd91ea6-78b4-5bfe-93e3-686fbef9f678","stable_key":"import-a8bedee0-a740-5bbb-921e-bfd144c7b68c","title":"Astaxanthin: transport, membrane chemistry, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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