{"id":"da095b14-5470-55bb-8563-ffe61bfd98d3","stable_key":"584c58f5-ab9f-53f3-97a9-55783db943b0:tryptophan-tdo-ahr","predicate":"associated_pathway_activates","statement":"Human tumor-cell TDO-derived kynurenine supported AHR-dependent survival and motility in the study.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"6c67a52c-f130-5268-bac5-a87e8d9fee6e","mechanism_event_label":"The catabolic route could feed a tumor-associated signal.","subject":{"id":"ce72cbd6-7077-5f23-a859-a8000a3f8194","slug":"kynurenine","display_name":"L-Kynurenine","entity_type_key":"small_molecule"},"object":{"id":"757ea2d0-1c8e-5453-a721-4a3a3443a383","slug":"ahr","display_name":"Human aryl hydrocarbon receptor / AHR","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"6c67a52c-f130-5268-bac5-a87e8d9fee6e","stable_key":"584c58f5-ab9f-53f3-97a9-55783db943b0:tryptophan-tdo-ahr-event","event_type":"observed_relationship","label":"The catabolic route could feed a tumor-associated signal.","description":"Human tumor-cell TDO-derived kynurenine supported AHR-dependent survival and motility in the study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ce72cbd6-7077-5f23-a859-a8000a3f8194","slug":"kynurenine","display_name":"L-Kynurenine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"757ea2d0-1c8e-5453-a721-4a3a3443a383","slug":"ahr","display_name":"Human aryl hydrocarbon receptor / AHR","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"769339cb-213b-559e-acc0-07ed00368b94","slug":"l-tryptophan","display_name":"L-Tryptophan","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"069155e2-e27b-55c2-85e3-b4a96bc91876","slug":"tdo2","display_name":"Human tryptophan 2,3-dioxygenase / TDO2","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"b251efe7-e8c3-55a2-a13d-ff31478a5121","slug":"human-tumor-ahr-motility","display_name":"Human tumor-cell AHR-dependent motility and survival","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human tumor-cell experiments with human brain-tumor associations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The chemical identity of the active ligand requires care: later work identified potent trace kynurenine condensation products.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Tryptophan collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-tryptophan","display_name":"L-Tryptophan","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The catabolic route could feed a tumor-associated signal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21976023/ · DOI 10.1038/nature10491","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2423138f-7934-5f68-935a-da4441c73de1","evidence_kind":"source_excerpt","locator":"Lines 426-432","start_line":426,"end_line":432,"excerpt":"## tryptophan-tdo-ahr\nThe catabolic route could feed a tumor-associated signal.\nHuman tumor-cell TDO-derived kynurenine supported AHR-dependent survival and motility in the study.\nModel: Human tumor-cell experiments with human brain-tumor associations.\nLimitations: The chemical identity of the active ligand requires care: later work identified potent trace kynurenine condensation products.\nEvidence access: Primary abstract\nAn endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21976023/ · DOI 10.1038/nature10491","model_system":"Human tumor-cell experiments with human brain-tumor associations.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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