{"id":"d9e88f2f-279d-5e58-85b7-3690faf81cf8","stable_key":"aad5a443-96e9-52eb-963a-812e90f9f896:lycopene-vitamin-a-status","predicate":"dietary_deficiency_increased","statement":"Vitamin-A-deficient wild-type mice accumulated more hepatic lycopene than vitamin-A-sufficient mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"0a4df3cc-65ff-58fc-ba33-612b4c23bc8a","mechanism_event_label":"A shortage of one nutrient can change the handling of another compound.","subject":{"id":"ce392c9e-6483-5914-b18b-d6a2520dbbf6","slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"},"object":{"id":"8eec948a-6546-5596-b06e-12c2dc130540","slug":"mouse-hepatic-lycopene-content","display_name":"Mouse hepatic lycopene content","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"0a4df3cc-65ff-58fc-ba33-612b4c23bc8a","stable_key":"aad5a443-96e9-52eb-963a-812e90f9f896:lycopene-vitamin-a-status-event","event_type":"biochemical_relationship","label":"A shortage of one nutrient can change the handling of another compound.","description":"Vitamin-A-deficient wild-type mice accumulated more hepatic lycopene than vitamin-A-sufficient mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0b16e027-7a68-55ae-8e33-eae8b5cd1e9e","slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"},"role":"administered_carotenoid","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ce392c9e-6483-5914-b18b-d6a2520dbbf6","slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8eec948a-6546-5596-b06e-12c2dc130540","slug":"mouse-hepatic-lycopene-content","display_name":"Mouse hepatic lycopene content","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/lycopene-research/37269907.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"36b39754d4d3b4ed8721a15f8dffe03bfd387dcbef3ff50918daabb45c48e756\", \"start_char\": 0, \"end_char\": 1986, \"text_sha256\": \"36b39754d4d3b4ed8721a15f8dffe03bfd387dcbef3ff50918daabb45c48e756\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Carotenoid-enzyme knockout comparison and vitamin-A diet experiment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"1 mg lycopene in cottonseed oil daily for two weeks; separate vitamin-A-deficient versus sufficient diets","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Mouse knockout distribution does not directly quantify human cleavage; increased ISX signaling does not prove conversion to vitamin A.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lycopene research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Mouse","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A shortage of one nutrient can change the handling of another compound.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[lycopene-p37269907] Lycopene Accumulation in Transgenic Mice Lacking One or Both Carotenoid Cleaving Enzymes. (2023). https://pubmed.ncbi.nlm.nih.gov/37269907/ DOI: 10.1016/j.tjnut.2023.05.025","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Liver, other tissues and intestinal gene expression","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"c42b0c9a-0ef9-53c2-8397-ae687cf1d329","evidence_kind":"source_excerpt","locator":"Lines 806-817","start_line":806,"end_line":817,"excerpt":"### lycopene-vitamin-a-status\nVitamin-A-deficient wild-type mice accumulated more hepatic lycopene than vitamin-A-sufficient mice.\nCondition category: nutrient_deficiency\nnutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A shortage of one nutrient can change the handling of another compound.\norganism: Mouse\ntissue_or_cell_type: Liver, other tissues and intestinal gene expression\nexperimental_model: Carotenoid-enzyme knockout comparison and vitamin-A diet experiment\nlimitations: Mouse knockout distribution does not directly quantify human cleavage; increased ISX signaling does not prove conversion to vitamin A.\nexposure: 1 mg lycopene in cottonseed oil daily for two weeks; separate vitamin-A-deficient versus sufficient diets\nevidence_span: {\"source_cache\": \"artifacts/lycopene-research/37269907.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"36b39754d4d3b4ed8721a15f8dffe03bfd387dcbef3ff50918daabb45c48e756\", \"start_char\": 0, \"end_char\": 1986, \"text_sha256\": \"36b39754d4d3b4ed8721a15f8dffe03bfd387dcbef3ff50918daabb45c48e756\"}\n[lycopene-p37269907] Lycopene Accumulation in Transgenic Mice Lacking One or Both Carotenoid Cleaving Enzymes. 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