{"id":"d9e4d9d6-9bc1-5224-923f-d681f765e1f0","stable_key":"920dfea8-62e3-5bd4-8b18-d19f86eb8295:egt-sqor-gsh-acceptor","predicate":"transfers_sulfane_sulfur_to","statement":"Nanodisc-embedded human SQOR transferred sulfane sulfur to glutathione; kinetics supported GSH as the predominant physiological acceptor.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"b25b46fe-5fdf-52fb-b702-51523329c370","mechanism_event_label":"Glutathione also participates in disposal of sulfide-derived sulfur.","subject":{"id":"6ddb0a1d-9690-5a4b-a837-052d69c7b88b","slug":"sqor","display_name":"Human sulfide:quinone oxidoreductase / SQOR","entity_type_key":"protein"},"object":{"id":"26970c62-0910-5d32-85c7-aa08c4f624e8","slug":"glutathione-persulfide","display_name":"Glutathione persulfide / GSSH","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"b25b46fe-5fdf-52fb-b702-51523329c370","stable_key":"920dfea8-62e3-5bd4-8b18-d19f86eb8295:egt-sqor-gsh-acceptor-event","event_type":"biochemical_relationship","label":"Glutathione also participates in disposal of sulfide-derived sulfur.","description":"Nanodisc-embedded human SQOR transferred sulfane sulfur to glutathione; kinetics supported GSH as the predominant physiological acceptor.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6ddb0a1d-9690-5a4b-a837-052d69c7b88b","slug":"sqor","display_name":"Human sulfide:quinone oxidoreductase / SQOR","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"26970c62-0910-5d32-85c7-aa08c4f624e8","slug":"glutathione-persulfide","display_name":"Glutathione persulfide / GSSH","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b44c9e27-4bbb-52d3-a022-14cddded5073","slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"},"role":"sulfur acceptor","stoichiometry":null,"state_label":"reduced","sequence_order":2,"notes":""},{"entity":{"id":"70cc3ced-8adc-5e76-9750-e1415683455b","slug":"hydrogen-sulfide","display_name":"Hydrogen sulfide / H2S","entity_type_key":"small_molecule"},"role":"oxidized sulfur substrate","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"e2cd7179-f218-54e8-9ce9-7a836ae35fac","slug":"fad","display_name":"FAD","entity_type_key":"small_molecule"},"role":"electron relay cofactor","stoichiometry":null,"state_label":"bound","sequence_order":4,"notes":""},{"entity":{"id":"ae9544c3-df78-54f8-80e7-5b643e5ba1cf","slug":"ubiquinone","display_name":"Ubiquinone","entity_type_key":"small_molecule"},"role":"electron acceptor","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary indexed abstract. Physiological acceptor assignment is a kinetic interpretation, not a direct measurement of flux in a patient.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Purified human SQOR in nanodiscs; steady-state and rapid-kinetic assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived research curation; not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Predominant acceptor is a kinetic interpretation; alternative acceptors can work in other assay conditions. Ergothioneine and nutrient depletion were not tested.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ergothioneine mitochondrial supplement; shared molecular requirements are not demonstrated dietary interactions.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Glutathione also participates in disposal of sulfide-derived sulfur.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Landry et al. H2S oxidation by nanodisc-embedded human sulfide quinone oxidoreductase. DOI 10.1074/jbc.M117.788547; PMID 28512131; https://pubmed.ncbi.nlm.nih.gov/28512131/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Abstract","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"10a8abc1-2421-588b-985b-7f7b40855211","evidence_kind":"source_excerpt","locator":"Lines 137-137","start_line":137,"end_line":137,"excerpt":"Nanodisc-embedded human SQOR transferred sulfane sulfur to glutathione; kinetics supported GSH as the predominant physiological acceptor.","model_system":"Purified human SQOR in nanodiscs; steady-state and rapid-kinetic assays.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Evidence points to this original curation statement. 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