{"id":"d9c5d079-9c86-5981-8491-b22d8960e54e","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:ve-transport-hdl-route-mtp-independent","predicate":"is_secreted_via","statement":"Primary rodent enterocytes secreted alpha-tocopherol with HDL even without exogenous lipid; this secretion was not reduced by MTP inhibition.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"be1c8558-8d9c-5140-bb36-e34eef2dc3e2","mechanism_event_label":"A separate HDL-associated export route remained available in the experiment.","subject":{"id":"40a6525a-76b8-576e-b73d-1e11aecf5f8d","slug":"alpha-tocopherol","display_name":"Alpha-tocopherol","entity_type_key":"small_molecule"},"object":{"id":"4f151316-e047-554f-8a20-533d6a774d9e","slug":"hdl-alpha-tocopherol-secretion","display_name":"HDL-associated alpha-tocopherol secretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"be1c8558-8d9c-5140-bb36-e34eef2dc3e2","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:ve-transport-hdl-route-mtp-independent-event","event_type":"biochemical_relationship","label":"A separate HDL-associated export route remained available in the experiment.","description":"Primary rodent enterocytes secreted alpha-tocopherol with HDL even without exogenous lipid; this secretion was not reduced by MTP inhibition.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"40a6525a-76b8-576e-b73d-1e11aecf5f8d","slug":"alpha-tocopherol","display_name":"Alpha-tocopherol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4f151316-e047-554f-8a20-533d6a774d9e","slug":"hdl-alpha-tocopherol-secretion","display_name":"HDL-associated alpha-tocopherol secretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Primary rat/mouse enterocyte lipoprotein fractionation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Radiolabeled alpha-tocopherol; exogenous lipid omission and MTP inhibition comparisons.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Demonstrates a route, not adequate whole-body compensation for impaired chylomicron assembly.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin E research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-e","display_name":"Vitamin E","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Rattus norvegicus and Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A separate HDL-associated export route remained available in the experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[anwar2007] Mechanisms involved in vitamin E transport by primary enterocytes and in vivo absorption. (2007). https://pubmed.ncbi.nlm.nih.gov/17582142/ DOI: 10.1194/jlr.m700207-jlr200","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Small-intestinal enterocytes","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"71a24ca0-eb63-527d-b180-474c0263f325","evidence_kind":"source_excerpt","locator":"Lines 259-270","start_line":259,"end_line":270,"excerpt":"### ve-transport-hdl-route-mtp-independent\nPrimary rodent enterocytes secreted alpha-tocopherol with HDL even without exogenous lipid; this secretion was not reduced by MTP inhibition.\nCondition category: normal\nnutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A separate HDL-associated export route remained available in the experiment.\norganism: Rattus norvegicus and Mus musculus\ntissue_or_cell_type: Small-intestinal enterocytes\nexperimental_model: Primary rat/mouse enterocyte lipoprotein fractionation\nlimitations: Demonstrates a route, not adequate whole-body compensation for impaired chylomicron assembly.\nexposure: Radiolabeled alpha-tocopherol; exogenous lipid omission and MTP inhibition comparisons.\ncross_nutrient: false\n[anwar2007] Mechanisms involved in vitamin E transport by primary enterocytes and in vivo absorption. 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