{"id":"d9c30999-74a6-5352-b4fe-7463a72f4d12","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-pmn-hydroxyl","predicate":"reduces_measured_signal","statement":"KI suppressed measured PMN hydroxyl-radical generation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"7e3ad1f3-c51c-56d7-8379-3e6007055974","mechanism_event_label":"A second oxidant readout also fell.","subject":{"id":"d6a7fe6a-d90e-5fad-acf4-4971b24fa8d7","slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"},"object":{"id":"ef0437dd-6f01-5c76-bea7-01d496564355","slug":"hydroxyl-radical-assay-readout","display_name":"Hydroxyl-radical assay readout, method specified","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7e3ad1f3-c51c-56d7-8379-3e6007055974","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-pmn-hydroxyl-event","event_type":"observed_relationship","label":"A second oxidant readout also fell.","description":"KI suppressed measured PMN hydroxyl-radical generation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d6a7fe6a-d90e-5fad-acf4-4971b24fa8d7","slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ef0437dd-6f01-5c76-bea7-01d496564355","slug":"hydroxyl-radical-assay-readout","display_name":"Hydroxyl-radical assay readout, method specified","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"In-vitro polymorphonuclear leukocytes; tested drug concentrations reported as 10 micromolar–millimolar.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_category","value_text":"Study-specific exposure, including pharmacological and in-vitro conditions; normal is the schema fallback outside the three availability categories.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Assay effects do not identify a unique molecular target or establish universal antioxidant action.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium iodide research collection; shared-anion and comparator studies are not all KI interventions.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"A second oxidant readout also fell.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effects of potassium iodide, colchicine and dapsone on the generation of polymorphonuclear leukocyte-derived oxygen intermediates. · 1982 · https://pubmed.ncbi.nlm.nih.gov/7104217/ · DOI 10.1111/j.1365-2133.1982.tb00340.x","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e558b812-b483-59b5-9f6b-ae88865da9cf","evidence_kind":"source_excerpt","locator":"Lines 296-302","start_line":296,"end_line":302,"excerpt":"## ki-pmn-hydroxyl\nA second oxidant readout also fell.\nKI suppressed measured PMN hydroxyl-radical generation.\nModel: In-vitro polymorphonuclear leukocytes; tested drug concentrations reported as 10 micromolar–millimolar.\nLimitations: Assay effects do not identify a unique molecular target or establish universal antioxidant action.\nEvidence location: Primary abstract\nEffects of potassium iodide, colchicine and dapsone on the generation of polymorphonuclear leukocyte-derived oxygen intermediates. · 1982 · https://pubmed.ncbi.nlm.nih.gov/7104217/ · DOI 10.1111/j.1365-2133.1982.tb00340.x","model_system":"In-vitro polymorphonuclear leukocytes; tested drug concentrations reported as 10 micromolar–millimolar.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Curation paraphrase; primary evidence location and source kind retained above.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc3ce411-f68f-5eb8-87c1-1592665f9cb6","stable_key":"import-79018983-9179-5c1a-8e7a-d6f47a13582b","title":"Potassium iodide: thyroid and non-thyroid mechanisms, interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-study references, chemical references and label statements individually identified. Not publisher full text.","file_path":"","sha256":"3ff9da818dd7a763a59c6abcff2eaee136d7f887a777034feaa5ba304a8fa6ce","revision_id":"53f2ae88-8a91-5326-ac49-3bb510ca78c3","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}