{"id":"d9785d9c-27ed-50f7-a3aa-924337a77869","stable_key":"507ed066-fd6d-5722-9223-97b66302e7e3:glycine-glyr-ligand-kinetics","predicate":"has_distinct_kinetics_at","statement":"At saturating 30 mM agonist, human alpha1 glycine-receptor activation rose faster with glycine than beta-alanine or taurine, and glycine responses decayed more slowly after removal.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b7e55505-46ba-5727-ab2d-ab5b68337c1a","mechanism_event_label":"Related molecules activate the same receptor with different timing.","subject":{"id":"2b507258-430c-51fe-9fd2-e510c2c197a9","slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"},"object":{"id":"b40b5391-68b1-5939-86b2-fa3b7e7681d8","slug":"human-glra1-homomer","display_name":"Human alpha1 homomeric glycine receptor","entity_type_key":"protein_complex"},"evidence_count":1,"mechanism_event":{"id":"b7e55505-46ba-5727-ab2d-ab5b68337c1a","stable_key":"507ed066-fd6d-5722-9223-97b66302e7e3:glycine-glyr-ligand-kinetics-event","event_type":"observed_relationship","label":"Related molecules activate the same receptor with different timing.","description":"At saturating 30 mM agonist, human alpha1 glycine-receptor activation rose faster with glycine than beta-alanine or taurine, and glycine responses decayed more slowly after removal.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2b507258-430c-51fe-9fd2-e510c2c197a9","slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b40b5391-68b1-5939-86b2-fa3b7e7681d8","slug":"human-glra1-homomer","display_name":"Human alpha1 homomeric glycine receptor","entity_type_key":"protein_complex"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"288f19a6-62f0-51fe-8e6d-366388b6b16d","slug":"beta-alanine","display_name":"Beta-alanine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human recombinant receptor comparison using high agonist concentrations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not equivalent to relative sedative potency after oral intake.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Glycine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Related molecules activate the same receptor with different timing.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Kinetic determinants of agonist action at the recombinant human glycine receptor. · 2003 · https://pubmed.ncbi.nlm.nih.gov/12679369/ · DOI 10.1113/jphysiol.2002.037796","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"1c989e8f-2725-5e84-93d1-e6e7f4a5bd8a","evidence_kind":"source_excerpt","locator":"Lines 202-208","start_line":202,"end_line":208,"excerpt":"## glycine-glyr-ligand-kinetics\nRelated molecules activate the same receptor with different timing.\nAt saturating 30 mM agonist, human alpha1 glycine-receptor activation rose faster with glycine than beta-alanine or taurine, and glycine responses decayed more slowly after removal.\nModel: Human recombinant receptor comparison using high agonist concentrations.\nLimitations: Not equivalent to relative sedative potency after oral intake.\nEvidence access: Primary abstract\nKinetic determinants of agonist action at the recombinant human glycine receptor. · 2003 · https://pubmed.ncbi.nlm.nih.gov/12679369/ · DOI 10.1113/jphysiol.2002.037796","model_system":"Human recombinant receptor comparison using high agonist concentrations.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"7b2859d8-e2bf-51e7-8e32-0715c10cbc49","stable_key":"import-507ed066-fd6d-5722-9223-97b66302e7e3","title":"Glycine: supply, one-carbon allocation, receptors and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"4fabd2fc8e71ca156c91023e7340be3f5a02ae03e91d3a24b231c2adfb0de0aa","revision_id":"24801e49-34a8-53c3-bdf5-b59143441450","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}