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It shows the redox change is not fixed, which bears on reading any single acute measurement as the steady state.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ethanol","display_name":"Ethanol","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Baboon","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The redox hit shrinks with habitual drinking, so a first-drink measurement does not describe a heavy drinker.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[alcohol-p6793493] Attenuation of the ethanol-induced hepatic redox change after chronic alcohol consumption in baboons: metabolic consequences in vivo and in vitro. (1981). https://pubmed.ncbi.nlm.nih.gov/6793493/ DOI: 10.1002/hep.1840010106","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Liver","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b143918a-499b-5cbf-b562-e0cb647bbc46","evidence_kind":"source_excerpt","locator":"Lines 124-135","start_line":124,"end_line":135,"excerpt":"### alcohol-redox-adaptation\nThe ethanol-induced hepatic redox change was attenuated after chronic alcohol consumption in baboons, with metabolic consequences measured both in vivo and in vitro.\nCondition category: normal\nnutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes.\nplain_language: The redox hit shrinks with habitual drinking, so a first-drink measurement does not describe a heavy drinker.\norganism: Baboon\ntissue_or_cell_type: Liver\nexperimental_model: Baboons fed alcohol chronically, with in vivo and in vitro redox measurement\nlimitations: A primate chronic-feeding model. It shows the redox change is not fixed, which bears on reading any single acute measurement as the steady state.\nexposure: Chronic alcohol consumption compared with acute administration\nevidence_span: {\"source_cache\": \"artifacts/alcohol-research/6793493.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"5105956fd640dc7b32bd1d5e54a0df98bc5eb8d332220e27578ce5e631536fbe\", \"start_char\": 0, \"end_char\": 986, \"text_sha256\": \"5105956fd640dc7b32bd1d5e54a0df98bc5eb8d332220e27578ce5e631536fbe\"}\n[alcohol-p6793493] Attenuation of the ethanol-induced hepatic redox change after chronic alcohol consumption in baboons: metabolic consequences in vivo and in vitro. 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