{"id":"d90536dd-b4d2-5fc8-aada-d0170cd666a1","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-restriction-kynurenine-profile","predicate":"restriction_shifted_kynurenine_metabolites","statement":"3-Hydroxykynurenine increased 39% fasting and 34% after meals; kynurenic acid decreased 22% and 20%, respectively.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"82c8d86e-4f75-5b60-aa0d-45d232ddbb0c","mechanism_event_label":"Different branches of tryptophan processing left a detectable blood pattern.","subject":{"id":"c0beb226-8842-501f-a147-cac0d9fa7060","slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"},"object":{"id":"215d55a2-1657-589c-aaf4-afd1957859e7","slug":"3-hydroxykynurenine","display_name":"3-Hydroxy-L-kynurenine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"82c8d86e-4f75-5b60-aa0d-45d232ddbb0c","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-restriction-kynurenine-profile-event","event_type":"observed_intervention","label":"Different branches of tryptophan processing left a detectable blood pattern.","description":"3-Hydroxykynurenine increased 39% fasting and 34% after meals; kynurenic acid decreased 22% and 20%, respectively.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6a123629-5a43-57ef-bba0-c429005ab5b3","slug":"kynurenic-acid","display_name":"Kynurenic acid","entity_type_key":"small_molecule"},"role":"decreased_metabolite","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c0beb226-8842-501f-a147-cac0d9fa7060","slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"215d55a2-1657-589c-aaf4-afd1957859e7","slug":"3-hydroxykynurenine","display_name":"3-Hydroxy-L-kynurenine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"B6-dependent kynurenine reactions intersect the tryptophan-to-niacin network; conversion to NAD was not measured.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Twenty-three healthy adults; paired pre/postprandial LC-MS/MS metabolite profiling.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"28 days below 0.35 mg/day B6. Related restriction research program; do not count paper totals as independent trial replications.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not measure brain neurotransmitters, tissue NAD synthesis or diagnose niacin deficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Different branches of tryptophan processing left a detectable blood pattern.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b6-dasilva2013] Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women (2013). https://pubmed.ncbi.nlm.nih.gov/23966327/ DOI: 10.3945/jn.113.180588","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human blood and whole-body measurements","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"089ecec3-fd8e-509b-89f2-632b7143dd45","evidence_kind":"source_excerpt","locator":"Lines 1436-1447","start_line":1436,"end_line":1447,"excerpt":"### b6-restriction-kynurenine-profile\n3-Hydroxykynurenine increased 39% fasting and 34% after meals; kynurenic acid decreased 22% and 20%, respectively.\nCondition category: nutrient_deficiency\nnutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Different branches of tryptophan processing left a detectable blood pattern.\norganism: Homo sapiens\ntissue_or_cell_type: Human blood and whole-body measurements\nexperimental_model: Twenty-three healthy adults; paired pre/postprandial LC-MS/MS metabolite profiling.\nlimitations: Does not measure brain neurotransmitters, tissue NAD synthesis or diagnose niacin deficiency.\nexposure: 28 days below 0.35 mg/day B6. Related restriction research program; do not count paper totals as independent trial replications.\ncross_nutrient: B6-dependent kynurenine reactions intersect the tryptophan-to-niacin network; conversion to NAD was not measured.\n[b6-dasilva2013] Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women (2013). https://pubmed.ncbi.nlm.nih.gov/23966327/ DOI: 10.3945/jn.113.180588","model_system":"Twenty-three healthy adults; paired pre/postprandial LC-MS/MS metabolite profiling.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b6-dasilva2013] Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women (2013). https://pubmed.ncbi.nlm.nih.gov/23966327/ DOI: 10.3945/jn.113.180588","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"251773bb-16f5-5903-b135-db4a61d9dec4","stable_key":"import-1310afbd-6010-586e-805d-551d846da421","title":"Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ef0019b344b2219220f801a84d0d138ff6880c1be1a59540d9034bfa4334f61e","revision_id":"cac3555f-48af-5c52-a84e-add4482c87fb","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}