{"id":"d8a72999-0a4c-5b33-865b-09e4e220f0b4","stable_key":"be889add-cec8-500b-be89-676431432a70:mn-trans-slc30a10-global-excretion","predicate":"decreases","statement":"Whole-body Slc30a10 deficiency impaired systemic manganese excretion in mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"25a74f4e-a2e2-5cff-86d0-964cbe03e2e8","mechanism_event_label":"Loss of Slc30a10 throughout the body reduced manganese clearance.","subject":{"id":"dea8b66d-b613-57c5-940f-b55ac2ac4ed1","slug":"mouse-global-slc30a10-knockout","display_name":"Mouse whole-body Slc30a10 knockout genotype","entity_type_key":"gene"},"object":{"id":"f804b692-7d79-5451-8d69-93547e909a8c","slug":"systemic-manganese-excretion","display_name":"Systemic manganese excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"25a74f4e-a2e2-5cff-86d0-964cbe03e2e8","stable_key":"be889add-cec8-500b-be89-676431432a70:mn-trans-slc30a10-global-excretion-event","event_type":"biochemical_relationship","label":"Loss of Slc30a10 throughout the body reduced manganese clearance.","description":"Whole-body Slc30a10 deficiency impaired systemic manganese excretion in mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a8082b11-c484-5792-bb81-48e8e699cbe4","slug":"manganese-ion","display_name":"Mn2+","entity_type_key":"ion"},"role":"transported_substrate","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3241bcc4-1a56-525d-b130-53d562ea34ce","slug":"mouse-slc30a10","display_name":"Mouse manganese exporter Slc30a10","entity_type_key":"protein"},"role":"affected_transporter","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"dea8b66d-b613-57c5-940f-b55ac2ac4ed1","slug":"mouse-global-slc30a10-knockout","display_name":"Mouse whole-body Slc30a10 knockout genotype","entity_type_key":"gene"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"f804b692-7d79-5451-8d69-93547e909a8c","slug":"systemic-manganese-excretion","display_name":"Systemic manganese excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Whole-body and tissue-specific Slc30a10 knockout mice","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Whole-body Slc30a10-deficient mice versus controls.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Genetic manganese retention is manganese excess, not nutrient deficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Manganese research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"manganese","display_name":"Manganese","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Loss of Slc30a10 throughout the body reduced manganese clearance.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mn-trans-31527311] Manganese transporter Slc30a10 controls physiological manganese excretion and toxicity. 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