{"id":"d853662d-f0a7-56a9-abc9-52ed7824ce00","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-sig-dendritic-maturation","predicate":"increased_expression_inhibited","statement":"Zinc supplementation or increased Zip6 expression inhibited LPS-associated upregulation of MHC-II and costimulatory molecules in the dendritic-cell study.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"566b300b-0a0a-595a-a94d-30fa83371005","mechanism_event_label":"A lower zinc pool accompanied one dendritic-cell maturation response, illustrating cell-specific regulation.","subject":{"id":"15c51a95-da10-531b-afe1-e860bc034b76","slug":"mouse-slc39a6","display_name":"Mouse ZIP6 / Slc39a6","entity_type_key":"protein"},"object":{"id":"d5eb167b-c8dc-5ace-a016-c1c02e0d889b","slug":"dendritic-cell-maturation-markers","display_name":"Dendritic-cell MHC-II and costimulatory markers","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"566b300b-0a0a-595a-a94d-30fa83371005","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-sig-dendritic-maturation-event","event_type":"biochemical_relationship","label":"A lower zinc pool accompanied one dendritic-cell maturation response, illustrating cell-specific regulation.","description":"Zinc supplementation or increased Zip6 expression inhibited LPS-associated upregulation of MHC-II and costimulatory molecules in the dendritic-cell study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"49c806c2-7041-5020-8b3b-fa04ffa122ac","slug":"zinc-ion","display_name":"Zinc(II) ion","entity_type_key":"ion"},"role":"availability_modifier","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"15c51a95-da10-531b-afe1-e860bc034b76","slug":"mouse-slc39a6","display_name":"Mouse ZIP6 / Slc39a6","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"d5eb167b-c8dc-5ace-a016-c1c02e0d889b","slug":"dendritic-cell-maturation-markers","display_name":"Dendritic-cell MHC-II and costimulatory markers","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Zinc(II) ion (availability_modifier)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/zinc-signaling-sources/16892068-abstract.txt\", \"locator\": \"Primary indexed abstract\", \"file_sha256\": \"922aedddf1d5d49fc62e39285307917b93201e23b5b7ea57a60136edd6762a17\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Dendritic-cell signaling study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"LPS stimulation, zinc supplementation and Zip6 overexpression; exact doses and duration are not verified from the abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Cell-specific maturation markers are not a general measure of whole-person immune strength. Abstract supports endpoints without unverified protocol details.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Zinc research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A lower zinc pool accompanied one dendritic-cell maturation response, illustrating cell-specific regulation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[zn-sig-16892068] Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function. (2006). https://pubmed.ncbi.nlm.nih.gov/16892068/ DOI: 10.1038/ni1373","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Dendritic cells","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b56951d2-ed31-573a-bfbb-c1d67db6b021","evidence_kind":"source_excerpt","locator":"Lines 1069-1081","start_line":1069,"end_line":1081,"excerpt":"### zn-sig-dendritic-maturation\nZinc supplementation or increased Zip6 expression inhibited LPS-associated upregulation of MHC-II and costimulatory molecules in the dendritic-cell study.\nCondition category: normal\nnutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A lower zinc pool accompanied one dendritic-cell maturation response, illustrating cell-specific regulation.\norganism: Mus musculus\ntissue_or_cell_type: Dendritic cells\nexperimental_model: Dendritic-cell signaling study\nlimitations: Cell-specific maturation markers are not a general measure of whole-person immune strength. Abstract supports endpoints without unverified protocol details.\nexposure: LPS stimulation, zinc supplementation and Zip6 overexpression; exact doses and duration are not verified from the abstract.\ncross_nutrient: Zinc(II) ion (availability_modifier)\nevidence_span: {\"source_cache\": \"artifacts/zinc-signaling-sources/16892068-abstract.txt\", \"locator\": \"Primary indexed abstract\", \"file_sha256\": \"922aedddf1d5d49fc62e39285307917b93201e23b5b7ea57a60136edd6762a17\"}\n[zn-sig-16892068] Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function. (2006). https://pubmed.ncbi.nlm.nih.gov/16892068/ DOI: 10.1038/ni1373","model_system":"Dendritic-cell signaling study","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [zn-sig-16892068] Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function. 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