{"id":"d823c384-760f-523d-98bf-7030ba5ed3b3","stable_key":"ec174d5a-4903-5745-8646-df0e9d4265e8:folate-methyl-low-folate-choline","predicate":"low_intake_decreases","statement":"Combined low-folate/low-choline feeding lowered plasma choline by 28% in men and 25% in women.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"b2870f3b-18de-5991-a75f-803670ecaec8","mechanism_event_label":"Folate restriction strained choline markers during low choline intake.","subject":{"id":"e176a266-711e-5469-89da-3fb2d3f244ad","slug":"folate","display_name":"Folate (vitamin B9)","entity_type_key":"chemical_species"},"object":{"id":"8e1d19fd-ad66-575d-81c4-9122f78915e5","slug":"choline","display_name":"Choline","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"b2870f3b-18de-5991-a75f-803670ecaec8","stable_key":"ec174d5a-4903-5745-8646-df0e9d4265e8:folate-methyl-low-folate-choline-event","event_type":"biochemical_relationship","label":"Folate restriction strained choline markers during low choline intake.","description":"Combined low-folate/low-choline feeding lowered plasma choline by 28% in men and 25% in women.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e176a266-711e-5469-89da-3fb2d3f244ad","slug":"folate","display_name":"Folate (vitamin B9)","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8e1d19fd-ad66-575d-81c4-9122f78915e5","slug":"choline","display_name":"Choline","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"Folate and choline status are coupled.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Metabolic-unit depletion/repletion: 11 men, 10 women.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Men: 25 micrograms folate/238 mg choline daily; women: 56 micrograms/147 mg","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No functional choline deficiency by measured transaminase/lipid endpoints.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"folate","display_name":"Folate (vitamin B9)","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Folate restriction strained choline markers during low choline intake.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[jacob-1999] Folate nutriture alters choline status of women and men fed low choline diets (1999). https://pubmed.ncbi.nlm.nih.gov/10082779/ DOI: 10.1093/jn/129.3.712","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"e7c1f000-5deb-58d4-ba38-c8df5f38eacf","evidence_kind":"source_excerpt","locator":"Lines 693-704","start_line":693,"end_line":704,"excerpt":"### folate-methyl-low-folate-choline\nCombined low-folate/low-choline feeding lowered plasma choline by 28% in men and 25% in women.\nCondition category: nutrient_deficiency\nnutrient_topic: Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Folate restriction strained choline markers during low choline intake.\norganism: Homo sapiens\ntissue_or_cell_type: Plasma\nexperimental_model: Metabolic-unit depletion/repletion: 11 men, 10 women.\nlimitations: No functional choline deficiency by measured transaminase/lipid endpoints.\nexposure: Men: 25 micrograms folate/238 mg choline daily; women: 56 micrograms/147 mg\ncross_nutrient: Folate and choline status are coupled.\n[jacob-1999] Folate nutriture alters choline status of women and men fed low choline diets (1999). https://pubmed.ncbi.nlm.nih.gov/10082779/ DOI: 10.1093/jn/129.3.712","model_system":"Metabolic-unit depletion/repletion: 11 men, 10 women.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [jacob-1999] Folate nutriture alters choline status of women and men fed low choline diets (1999). https://pubmed.ncbi.nlm.nih.gov/10082779/ DOI: 10.1093/jn/129.3.712","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"f4ce1a62-9582-5f7a-84f5-a23d0e1bfc68","stable_key":"import-ec174d5a-4903-5745-8646-df0e9d4265e8","title":"Folate and folic acid: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e564d43989ece1006c95cd0748e9af6fe369074599a2eebba0a99ebff864b0dd","revision_id":"76674a33-b2a1-5e41-b71b-44399038ff7c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}