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species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Even closely related receptor variants can translate a signal differently.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Single-channel properties of recombinant AMPA receptors depend on RNA editing, splice variation, and subunit composition. · 1997 · https://pubmed.ncbi.nlm.nih.gov/8987736/ · DOI 10.1523/JNEUROSCI.17-01-00058.1997","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e91231aa-0ced-546e-97a1-61ae3eb9b40a","evidence_kind":"source_excerpt","locator":"Lines 250-256","start_line":250,"end_line":256,"excerpt":"## glutamate-ampa-splice\nEven closely related receptor variants can translate a signal differently.\nThe GluR4 flip variant conferred agonist-dependent conductance properties in the reported recombinant AMPA recordings.\nModel: HEK293 recombinant channel recordings with splice-variant comparisons.\nLimitations: An assay-specific receptor assembly is retained rather than assigning every AMPA receptor the same behavior.\nEvidence access: Primary abstract\nSingle-channel properties of recombinant AMPA receptors depend on RNA editing, splice variation, and subunit composition. · 1997 · https://pubmed.ncbi.nlm.nih.gov/8987736/ · DOI 10.1523/JNEUROSCI.17-01-00058.1997","model_system":"HEK293 recombinant channel recordings with splice-variant comparisons.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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