{"id":"d7d7b8f0-6cc1-53ec-8a50-b7e8c6f9b940","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:c-phytate-iron-inhibition-counteraction","predicate":"counteracts_phytate_inhibition_of_nonheme_iron_absorption","statement":"Added ascorbic acid significantly counteracted the inhibition of radiolabeled nonheme iron absorption caused by sodium phytate in wheat-roll meals.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"10d201b1-5de8-578b-90b6-00aa007ae9b0","mechanism_event_label":"Vitamin C helped offset an iron-absorption inhibitor in the tested meals.","subject":{"id":"2047867f-9872-53b2-a553-71c911d0695b","slug":"ascorbic-acid","display_name":"L-Ascorbic acid","entity_type_key":"small_molecule"},"object":{"id":"4429d8ae-d732-5f5e-acc1-2c872e23da62","slug":"nonheme-iron-absorption","display_name":"Nonheme iron absorption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"10d201b1-5de8-578b-90b6-00aa007ae9b0","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:c-phytate-iron-inhibition-counteraction-event","event_type":"observed_intervention","label":"Vitamin C helped offset an iron-absorption inhibitor in the tested meals.","description":"Added ascorbic acid significantly counteracted the inhibition of radiolabeled nonheme iron absorption caused by sodium phytate in wheat-roll meals.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f64ba327-66e7-52b6-9424-7d7ec11acca4","slug":"phytic-acid","display_name":"Phytic acid / phytate","entity_type_key":"small_molecule"},"role":"absorption_inhibitor","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"affected_nutrient","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2047867f-9872-53b2-a553-71c911d0695b","slug":"ascorbic-acid","display_name":"L-Ascorbic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"4429d8ae-d732-5f5e-acc1-2c872e23da62","slug":"nonheme-iron-absorption","display_name":"Nonheme iron absorption","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Meal composition modifies the vitamin C/iron interaction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human alternate-day paired radiolabeled wheat-roll experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Seven sodium phytate levels spanning 2–250 mg expressed as phytate phosphorus, with and without ascorbic acid; 55Fe/59Fe labels. Exact C dose and participant count are not extracted from the abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Single-meal tracer result; does not prove full cancellation of inhibition or long-term correction of anemia.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin C research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Vitamin C helped offset an iron-absorption inhibitor in the tested meals.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[c-hallberg1989] Iron absorption in man: ascorbic acid and dose-dependent inhibition by phytate (1989). https://pubmed.ncbi.nlm.nih.gov/2911999/ DOI: 10.1093/ajcn/49.1.140","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human blood or whole-person endpoints","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6d732c9c-c30f-5532-9d4b-dab5983083a7","evidence_kind":"source_excerpt","locator":"Lines 1580-1591","start_line":1580,"end_line":1591,"excerpt":"### c-phytate-iron-inhibition-counteraction\nAdded ascorbic acid significantly counteracted the inhibition of radiolabeled nonheme iron absorption caused by sodium phytate in wheat-roll meals.\nCondition category: normal\nnutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Vitamin C helped offset an iron-absorption inhibitor in the tested meals.\norganism: Homo sapiens\ntissue_or_cell_type: Human blood or whole-person endpoints\nexperimental_model: Human alternate-day paired radiolabeled wheat-roll experiments.\nlimitations: Single-meal tracer result; does not prove full cancellation of inhibition or long-term correction of anemia.\nexposure: Seven sodium phytate levels spanning 2–250 mg expressed as phytate phosphorus, with and without ascorbic acid; 55Fe/59Fe labels. Exact C dose and participant count are not extracted from the abstract.\ncross_nutrient: Meal composition modifies the vitamin C/iron interaction.\n[c-hallberg1989] Iron absorption in man: ascorbic acid and dose-dependent inhibition by phytate (1989). https://pubmed.ncbi.nlm.nih.gov/2911999/ DOI: 10.1093/ajcn/49.1.140","model_system":"Human alternate-day paired radiolabeled wheat-roll experiments.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [c-hallberg1989] Iron absorption in man: ascorbic acid and dose-dependent inhibition by phytate (1989). https://pubmed.ncbi.nlm.nih.gov/2911999/ DOI: 10.1093/ajcn/49.1.140","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"fa811221-13bd-5c10-adc1-eaf097c7703c","stable_key":"import-cb568d28-484a-5c2e-9fcc-2d780358e514","title":"Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b7fd83f956abb81855f2ea23199ba14e465cd91f4a2ac560277ec21ddafd7bfc","revision_id":"6cde9bbb-d712-5746-82a6-85b144253efa","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}