{"id":"d7bdd104-f9bc-5113-a9ee-3cad7d525f66","stable_key":"c932089b-ebc9-5f39-b2e5-84af74f9f6d0:sucrose-exercise-muscle","predicate":"does_not_prevent_depletion","statement":"Muscle glycogen declined during prolonged cycling despite sucrose ingestion, as it did with glucose ingestion.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a37be93d-0349-573d-8e68-deb0db4d836c","mechanism_event_label":"Muscle glycogen declined during prolonged cycling despite sucrose ingestion, as it did with glucose ingestion.","subject":{"id":"82558bd0-1a84-574a-a04c-10609c9c5dba","slug":"sucrose","display_name":"Sucrose","entity_type_key":"small_molecule"},"object":{"id":"32044396-edea-58e1-99a5-adba02193e48","slug":"human-muscle-glycogen-use","display_name":"Human exercise muscle glycogen utilization","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a37be93d-0349-573d-8e68-deb0db4d836c","stable_key":"c932089b-ebc9-5f39-b2e5-84af74f9f6d0:sucrose-exercise-muscle-event","event_type":"observed_relationship","label":"Muscle glycogen declined during prolonged cycling despite sucrose ingestion, as it did with glucose ingestion.","description":"Muscle glycogen declined during prolonged cycling despite sucrose ingestion, as it did with glucose ingestion.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"82558bd0-1a84-574a-a04c-10609c9c5dba","slug":"sucrose","display_name":"Sucrose","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"32044396-edea-58e1-99a5-adba02193e48","slug":"human-muscle-glycogen-use","display_name":"Human exercise muscle glycogen utilization","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8ae7848b-f172-5e09-8acf-5ca914907b0b","slug":"glucose","display_name":"D-glucose","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"05c4c656-fd3f-55da-850b-3eea7fb0bc4b","slug":"glycogen","display_name":"Glycogen","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Sucrose or glucose 1.7 g/min, 102 g/hour, during cycling at 50% peak power","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"3 hours","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract/metadata; unrecovered methods explicitly retained.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; source-specific curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"14 trained cyclists in crossover; four completed additional water reference trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_scope","value_text":"Exercise fuel, not sedentary beverage exposure","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Water reference had four participants, not all 14. Whole-body utilization is not isolated exogenous sucrose oxidation. No demonstrated sucrose advantage for liver glycogen preservation. NCT02110836; Sugar Nutrition UK sponsor listed in trial record.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Sucrose chapter; direct sucrose observations are distinguished from shared component metabolism.","comparator":null,"unit":null,"notes":"","entity":{"slug":"sucrose","display_name":"Sucrose","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"14 trained cyclists in crossover; four completed additional water reference trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Muscle glycogen declined during prolonged cycling despite sucrose ingestion, as it did with glucose ingestion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Ingestion of glucose or sucrose prevents liver but not muscle glycogen depletion during prolonged endurance-type exercise in trained cyclists. (2015). https://pubmed.ncbi.nlm.nih.gov/26487008/ DOI: 10.1152/ajpendo.00376.2015","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral carbohydrate during exercise","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Liver and muscle glycogen by carbon-13 MRS; expired-gas substrate use","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ee5cc3af-b48d-57dd-986c-123461aa7ab2","evidence_kind":"source_excerpt","locator":"Lines 307-317","start_line":307,"end_line":317,"excerpt":"## sucrose-exercise-muscle\nMuscle glycogen declined during prolonged cycling despite sucrose ingestion, as it did with glucose ingestion.\nModel/species: 14 trained cyclists in crossover; four completed additional water reference trial\nTissue: Liver and muscle glycogen by carbon-13 MRS; expired-gas substrate use\nExposure: Sucrose or glucose 1.7 g/min, 102 g/hour, during cycling at 50% peak power\nRoute: Oral carbohydrate during exercise\nDuration: 3 hours\nExposure scope: Exercise fuel, not sedentary beverage exposure\nLimits: Water reference had four participants, not all 14. Whole-body utilization is not isolated exogenous sucrose oxidation. No demonstrated sucrose advantage for liver glycogen preservation. NCT02110836; Sugar Nutrition UK sponsor listed in trial record.\nReference: Ingestion of glucose or sucrose prevents liver but not muscle glycogen depletion during prolonged endurance-type exercise in trained cyclists. (2015). https://pubmed.ncbi.nlm.nih.gov/26487008/ DOI: 10.1152/ajpendo.00376.2015\nAccess: Primary abstract/metadata; unrecovered methods explicitly retained.","model_system":"14 trained cyclists in crossover; four completed additional water reference trial","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span, not a publisher quotation; provenance retained.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"8e24ddf4-84ee-57b4-9fd8-093547432ece","stable_key":"import-c932089b-ebc9-5f39-b2e5-84af74f9f6d0","title":"Sucrose: mechanism of action and metabolic impact (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific sucrose curation with shared canonical claims retained by identity. Primary-study citations, negative findings, exposure details and limitations preserved. Not publisher full text.","file_path":"","sha256":"5e68ccbade7a80fc03778495756f0eeeeba5038cd10d5bef8e33cb1e93e4b044","revision_id":"6edb8ffc-11c5-5cd9-852c-85adb71165a8","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}