{"id":"d78012fb-70de-596c-beb4-352a0002b3fc","stable_key":"e1af6d55-ced5-56c9-9a2d-8cc2ae6ec3ff:nasunin-linoleate-autoxidation","predicate":"inhibited","statement":"Nasunin inhibited linoleic acid autoxidation at pH 2.8 more strongly than delphinidin.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"82986a09-0eec-56c8-a821-f16fb63ff0d7","mechanism_event_label":"Chemical decorations altered performance in this acidic assay.","subject":{"id":"6553997f-f098-5507-95b4-0fdb8aac491d","slug":"nasunin","display_name":"Nasunin","entity_type_key":"small_molecule"},"object":{"id":"a20cde1f-0697-5297-ae49-735bfe7bd33f","slug":"linoleic-acid-autoxidation","display_name":"Linoleic acid autoxidation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"82986a09-0eec-56c8-a821-f16fb63ff0d7","stable_key":"e1af6d55-ced5-56c9-9a2d-8cc2ae6ec3ff:nasunin-linoleate-autoxidation-event","event_type":"biochemical_relationship","label":"Chemical decorations altered performance in this acidic assay.","description":"Nasunin inhibited linoleic acid autoxidation at pH 2.8 more strongly than delphinidin.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8744fb0d-739e-52cc-ac18-2f00ac889720","slug":"linoleic-acid","display_name":"Linoleic acid","entity_type_key":"small_molecule"},"role":"assay_substrate","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"35f028a1-9a8b-5983-8d02-53c5fb091d38","slug":"delphinidin","display_name":"Delphinidin","entity_type_key":"small_molecule"},"role":"comparison","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"6553997f-f098-5507-95b4-0fdb8aac491d","slug":"nasunin","display_name":"Nasunin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"a20cde1f-0697-5297-ae49-735bfe7bd33f","slug":"linoleic-acid-autoxidation","display_name":"Linoleic acid autoxidation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/nasunin-research/oxidation1993.publisher-abstract.txt\", \"locator\": \"Primary publisher abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"f5cd9a7913480b3dabe167e043aa03028e74ba6d0a57ada4ca50773ee9b16dee\", \"start_char\": 0, \"end_char\": 1041, \"text_sha256\": \"f5cd9a7913480b3dabe167e043aa03028e74ba6d0a57ada4ca50773ee9b16dee\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Carotene bleaching and linoleic acid autoxidation assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Carotene assay pH 7; linoleic acid autoxidation pH 2.8","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The structure-activity interpretation is tentative and assay-specific; no vitamin A absorption or systemic vitamin-sparing effect was tested.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Nasunin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"nasunin","display_name":"Nasunin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Cell-free chemistry","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Chemical decorations altered performance in this acidic assay.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[nasunin-poxidation1993] Antioxidative Activity of Nasunin in Chouja-nasu (Little Eggplant, Solanum melongena L. 'Chouja'). (1993). https://www.jstage.jst.go.jp/article/nskkk1962/40/2/40_2_138/_article DOI: 10.3136/nskkk1962.40.138","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Pigment and lipid oxidation","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"fafe6405-c691-56b3-809a-73b2b851d1f5","evidence_kind":"source_excerpt","locator":"Lines 614-625","start_line":614,"end_line":625,"excerpt":"### nasunin-linoleate-autoxidation\nNasunin inhibited linoleic acid autoxidation at pH 2.8 more strongly than delphinidin.\nCondition category: normal\nnutrient_topic: Nasunin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Chemical decorations altered performance in this acidic assay.\norganism: Cell-free chemistry\ntissue_or_cell_type: Pigment and lipid oxidation\nexperimental_model: Carotene bleaching and linoleic acid autoxidation assays\nlimitations: The structure-activity interpretation is tentative and assay-specific; no vitamin A absorption or systemic vitamin-sparing effect was tested.\nexposure: Carotene assay pH 7; linoleic acid autoxidation pH 2.8\nevidence_span: {\"source_cache\": \"artifacts/nasunin-research/oxidation1993.publisher-abstract.txt\", \"locator\": \"Primary publisher abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"f5cd9a7913480b3dabe167e043aa03028e74ba6d0a57ada4ca50773ee9b16dee\", \"start_char\": 0, \"end_char\": 1041, \"text_sha256\": \"f5cd9a7913480b3dabe167e043aa03028e74ba6d0a57ada4ca50773ee9b16dee\"}\n[nasunin-poxidation1993] Antioxidative Activity of Nasunin in Chouja-nasu (Little Eggplant, Solanum melongena L. 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