{"id":"d76ea751-d611-5e74-8f54-37c2cfc5fcf0","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-chemotaxis","predicate":"reduces","statement":"After KI 15 mg/kg/day for three days, peripheral neutrophil chemotaxis decreased in 15 healthy subjects.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"7ae3b7aa-33de-5740-9117-04ff9be0eeea","mechanism_event_label":"KI changed how neutrophils moved toward a signal.","subject":{"id":"d6a7fe6a-d90e-5fad-acf4-4971b24fa8d7","slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"},"object":{"id":"a67662f9-68ba-5e2c-bbd6-dd8f87e32724","slug":"neutrophil-chemotaxis","display_name":"Neutrophil chemotaxis","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7ae3b7aa-33de-5740-9117-04ff9be0eeea","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-chemotaxis-event","event_type":"observed_relationship","label":"KI changed how neutrophils moved toward a signal.","description":"After KI 15 mg/kg/day for three days, peripheral neutrophil chemotaxis decreased in 15 healthy subjects.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d6a7fe6a-d90e-5fad-acf4-4971b24fa8d7","slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a67662f9-68ba-5e2c-bbd6-dd8f87e32724","slug":"neutrophil-chemotaxis","display_name":"Neutrophil chemotaxis","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Human exposure; modified Boyden-chamber assay.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_category","value_text":"Study-specific exposure, including pharmacological and in-vitro conditions; normal is the schema fallback outside the three availability categories.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small mechanistic study; disease benefit was proposed rather than demonstrated.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium iodide research collection; shared-anion and comparator studies are not all KI interventions.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"KI changed how neutrophils moved toward a signal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Potassium iodide inhibits neutrophil chemotaxis. · 1990 · https://pubmed.ncbi.nlm.nih.gov/1972841/","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0b4b63da-d92e-5d82-830c-62bf158caf9c","evidence_kind":"source_excerpt","locator":"Lines 280-286","start_line":280,"end_line":286,"excerpt":"## ki-chemotaxis\nKI changed how neutrophils moved toward a signal.\nAfter KI 15 mg/kg/day for three days, peripheral neutrophil chemotaxis decreased in 15 healthy subjects.\nModel: Human exposure; modified Boyden-chamber assay.\nLimitations: Small mechanistic study; disease benefit was proposed rather than demonstrated.\nEvidence location: Primary abstract\nPotassium iodide inhibits neutrophil chemotaxis. · 1990 · https://pubmed.ncbi.nlm.nih.gov/1972841/","model_system":"Human exposure; modified Boyden-chamber assay.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Curation paraphrase; primary evidence location and source kind retained above.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc3ce411-f68f-5eb8-87c1-1592665f9cb6","stable_key":"import-79018983-9179-5c1a-8e7a-d6f47a13582b","title":"Potassium iodide: thyroid and non-thyroid mechanisms, interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-study references, chemical references and label statements individually identified. Not publisher full text.","file_path":"","sha256":"3ff9da818dd7a763a59c6abcff2eaee136d7f887a777034feaa5ba304a8fa6ce","revision_id":"53f2ae88-8a91-5326-ac49-3bb510ca78c3","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}