{"id":"d74b1026-f85b-5323-a76e-203f1527e757","stable_key":"4df6a932-097e-563a-91fe-5dceec471ffd:chloride-macula-chloride-renin","predicate":"inhibits","statement":"Adding luminal choline chloride or RbCl reduced renin release, whereas the tested sodium salts without chloride did not.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"2275ac87-4146-5eaf-b61f-2bbcdb46f9ab","mechanism_event_label":"The kidney’s salt sensor responded specifically to chloride delivery in this experiment.","subject":{"id":"6f35aa38-f875-5759-b749-97a2f6480ff3","slug":"chloride-ion","display_name":"Chloride ion","entity_type_key":"ion"},"object":{"id":"78d44150-e83e-5ff4-ac6c-cf395b173571","slug":"renin-secretion","display_name":"Juxtaglomerular renin secretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2275ac87-4146-5eaf-b61f-2bbcdb46f9ab","stable_key":"4df6a932-097e-563a-91fe-5dceec471ffd:chloride-macula-chloride-renin-event","event_type":"biochemical_relationship","label":"The kidney’s salt sensor responded specifically to chloride delivery in this experiment.","description":"Adding luminal choline chloride or RbCl reduced renin release, whereas the tested sodium salts without chloride did not.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6f35aa38-f875-5759-b749-97a2f6480ff3","slug":"chloride-ion","display_name":"Chloride ion","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"78d44150-e83e-5ff4-ac6c-cf395b173571","slug":"renin-secretion","display_name":"Juxtaglomerular renin secretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chloride-research/2012204.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"8ce0dd9b0315d2f3148f4edcc7d2e511984122ac2d50fa813a03e9b473b73dac\", \"start_char\": 0, \"end_char\": 1695, \"text_sha256\": \"8ce0dd9b0315d2f3148f4edcc7d2e511984122ac2d50fa813a03e9b473b73dac\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Perfused isolated juxtaglomerular apparatus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Luminal ion substitutions and 1 µM bumetanide","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Tubular luminal signal; plasma chloride alone does not reproduce it.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chloride research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chloride","display_name":"Chloride","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Rabbit","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The kidney’s salt sensor responded specifically to chloride delivery in this experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chloride-p2012204] Renin release from isolated juxtaglomerular apparatus depends on macula densa chloride transport. 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