{"id":"d701ece9-7d4d-5ed6-9b75-d34cc83612d4","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-bp-trial","predicate":"reduces","statement":"In 120 adults with prehypertension randomized to 1.6 g/day taurine or placebo for 12 weeks, clinic systolic pressure fell by 7.2 versus 2.6 mmHg and ambulatory systolic pressure by 3.8 versus 0.3 mmHg.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"cacc2d9e-3137-5d6c-ab38-3e687ac6fa69","mechanism_event_label":"One controlled trial found a modest blood-pressure reduction.","subject":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"object":{"id":"515f4066-3cbe-5542-85d5-a1652c3c00e0","slug":"human-taurine-blood-pressure","display_name":"Blood pressure in the 120-participant taurine trial","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"cacc2d9e-3137-5d6c-ab38-3e687ac6fa69","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-bp-trial-event","event_type":"observed_relationship","label":"One controlled trial found a modest blood-pressure reduction.","description":"In 120 adults with prehypertension randomized to 1.6 g/day taurine or placebo for 12 weeks, clinic systolic pressure fell by 7.2 versus 2.6 mmHg and ambulatory systolic pressure by 3.8 versus 0.3 mmHg.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"515f4066-3cbe-5542-85d5-a1652c3c00e0","slug":"human-taurine-blood-pressure","display_name":"Blood pressure in the 120-participant taurine trial","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized double-blind placebo-controlled human trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"These are within-arm changes; the trial did not establish long-term cardiovascular-event reduction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"One controlled trial found a modest blood-pressure reduction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study. · 2016 · https://pubmed.ncbi.nlm.nih.gov/26781281/ · DOI 10.1161/HYPERTENSIONAHA.115.06624","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"50b59758-a16b-53bb-bfdc-68083a673a20","evidence_kind":"source_excerpt","locator":"Lines 473-479","start_line":473,"end_line":479,"excerpt":"## taurine-bp-trial\nOne controlled trial found a modest blood-pressure reduction.\nIn 120 adults with prehypertension randomized to 1.6 g/day taurine or placebo for 12 weeks, clinic systolic pressure fell by 7.2 versus 2.6 mmHg and ambulatory systolic pressure by 3.8 versus 0.3 mmHg.\nModel: Randomized double-blind placebo-controlled human trial.\nLimitations: These are within-arm changes; the trial did not establish long-term cardiovascular-event reduction.\nEvidence access: Primary abstract\nTaurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study. · 2016 · https://pubmed.ncbi.nlm.nih.gov/26781281/ · DOI 10.1161/HYPERTENSIONAHA.115.06624","model_system":"Randomized double-blind placebo-controlled human trial.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc8d9ab8-fdf9-5107-877c-336cf8005097","stable_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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