{"id":"d6cc0850-63c1-5b5b-9a96-4dcedd54f086","stable_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:serotonin-regions","predicate":"increases_in_recorded_experiment","statement":"Modafinil increased extracellular serotonin in cortex, amygdala and dorsal raphe at lower doses than required in medial preoptic/posterior hypothalamic regions.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"1bb6cdfd-ae6e-5e8a-ac89-6ba51fed4e0f","mechanism_event_label":"Modafinil increased extracellular serotonin in cortex, amygdala and dorsal raphe at lower doses than required in medial preoptic/posterior hypothalamic regions.","subject":{"id":"624e6a4b-f96d-5d12-8206-30d1e1715c26","slug":"modafinil","display_name":"Modafinil","entity_type_key":"drug"},"object":{"id":"ecf988bf-ea11-5676-800e-c6c89f03441a","slug":"rat-serotonin-extracellular","display_name":"Rat regional extracellular serotonin","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1bb6cdfd-ae6e-5e8a-ac89-6ba51fed4e0f","stable_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:serotonin-regions-event","event_type":"experimental_observation","label":"Modafinil increased extracellular serotonin in cortex, amygdala and dorsal raphe at lower doses than required in medial preoptic/posterior hypothalamic regions.","description":"| Serotonin | In awake rats, extracellular serotonin increased in cortex, amygdala and dorsal raphe at lower tested doses than those needed in medial preoptic/posterior hypothalamic regions. | Uniform serotonin elevation or identification of SERT as the principal clinical target. 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