{"id":"d6b7d01b-5176-56f2-ae69-927ad2276aff","stable_key":"e37461ea-ea5d-5e2c-8091-138305f6dd70:l-aspartate-infant-oxidation","predicate":"supplies_oxidized_carbon","statement":"About 80 ± 9% of labeled aspartate carbon used in first-pass metabolism was recovered in expired carbon dioxide.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b2a8fc2a-6641-52b0-a044-2c46278fb281","mechanism_event_label":"The tracing supports extensive use of the carbon skeleton for energy metabolism.","subject":{"id":"0a0923d3-72b7-5d6a-bf3a-5a7a3071a09b","slug":"l-aspartate","display_name":"L-Aspartate","entity_type_key":"small_molecule"},"object":{"id":"6329ac30-3995-596a-803e-95d036082d86","slug":"preterm-infant-aspartate-breath-co2","display_name":"Breath carbon dioxide from first-pass aspartate in infants","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b2a8fc2a-6641-52b0-a044-2c46278fb281","stable_key":"e37461ea-ea5d-5e2c-8091-138305f6dd70:l-aspartate-infant-oxidation-event","event_type":"observed_relationship","label":"The tracing supports extensive use of the carbon skeleton for energy metabolism.","description":"About 80 ± 9% of labeled aspartate carbon used in first-pass metabolism was recovered in expired carbon dioxide.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0a0923d3-72b7-5d6a-bf3a-5a7a3071a09b","slug":"l-aspartate","display_name":"L-Aspartate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6329ac30-3995-596a-803e-95d036082d86","slug":"preterm-infant-aspartate-breath-co2","display_name":"Breath carbon dioxide from first-pass aspartate in infants","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same eight preterm infants; carbon-13 recovery in breath.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The denominator is label used in first pass, not necessarily the entire administered dose; no adult efficacy inference.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Aspartate collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-aspartate","display_name":"L-Aspartate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The tracing supports extensive use of the carbon skeleton for energy metabolism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Almost all enteral aspartate is taken up in first-pass metabolism in enterally fed preterm infants. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20022677/ · DOI 10.1016/j.clnu.2009.11.008","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0608fa3f-6729-5b1d-9d3c-e48cd6fae5b5","evidence_kind":"source_excerpt","locator":"Lines 26-32","start_line":26,"end_line":32,"excerpt":"## l-aspartate-infant-oxidation\nThe tracing supports extensive use of the carbon skeleton for energy metabolism.\nAbout 80 ± 9% of labeled aspartate carbon used in first-pass metabolism was recovered in expired carbon dioxide.\nModel: Same eight preterm infants; carbon-13 recovery in breath.\nLimitations: The denominator is label used in first pass, not necessarily the entire administered dose; no adult efficacy inference.\nEvidence access: Primary abstract\nAlmost all enteral aspartate is taken up in first-pass metabolism in enterally fed preterm infants. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20022677/ · DOI 10.1016/j.clnu.2009.11.008","model_system":"Same eight preterm infants; carbon-13 recovery in breath.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"67970dcb-34e0-5b0a-8c86-d8c3cc183444","stable_key":"import-e37461ea-ea5d-5e2c-8091-138305f6dd70","title":"L-Aspartate: redox transfer, nitrogen partitioning and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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