{"id":"d6942405-733a-5b90-a0c4-00e78071501a","stable_key":"0ad8610d-d575-5870-b7cd-763a9f750783:copper-ccs-selective-copper-route","predicate":"loss_spares","statement":"Ccs deletion did not measurably disrupt overall copper uptake, distribution or incorporation into the other cuproenzymes examined.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"f1d209e7-f880-53a6-8eb6-1e37087dd148","mechanism_event_label":"A broken delivery route can affect one enzyme while other copper routes keep working.","subject":{"id":"9dce69fb-cc03-54d0-8cd9-4f801c00bf42","slug":"mouse-ccs","display_name":"Mouse copper chaperone for SOD1 / Ccs","entity_type_key":"protein"},"object":{"id":"00ad835a-b52b-5ea9-ba2c-db4b73c00cdd","slug":"cellular-copper-uptake","display_name":"Cellular copper uptake","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f1d209e7-f880-53a6-8eb6-1e37087dd148","stable_key":"0ad8610d-d575-5870-b7cd-763a9f750783:copper-ccs-selective-copper-route-event","event_type":"biochemical_relationship","label":"A broken delivery route can affect one enzyme while other copper routes keep working.","description":"Ccs deletion did not measurably disrupt overall copper uptake, distribution or incorporation into the other cuproenzymes examined.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9dce69fb-cc03-54d0-8cd9-4f801c00bf42","slug":"mouse-ccs","display_name":"Mouse copper chaperone for SOD1 / Ccs","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"00ad835a-b52b-5ea9-ba2c-db4b73c00cdd","slug":"cellular-copper-uptake","display_name":"Cellular copper uptake","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/copper-research/10694572.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a8c8eb387b7e9d62e19f8de4ab12db826bbda965d5e673391bff49cb7ffe99ad\", \"start_char\": 0, \"end_char\": 1205, \"text_sha256\": \"a8c8eb387b7e9d62e19f8de4ab12db826bbda965d5e673391bff49cb7ffe99ad\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Ccs knockout mice and radiocopper labeling","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Ccs deletion","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Normal protein abundance can coexist with low activity; the phenotype does not establish a general dietary copper deficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Copper research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"copper","display_name":"Copper","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mouse","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A broken delivery route can affect one enzyme while other copper routes keep working.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[copper-p10694572] Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase. (2000). https://pubmed.ncbi.nlm.nih.gov/10694572/ DOI: 10.1073/pnas.040461197","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Multiple tissues and SOD1 protein","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"55528618-c035-56ba-b06e-da6c583d94a8","evidence_kind":"source_excerpt","locator":"Lines 754-765","start_line":754,"end_line":765,"excerpt":"### copper-ccs-selective-copper-route\nCcs deletion did not measurably disrupt overall copper uptake, distribution or incorporation into the other cuproenzymes examined.\nCondition category: machinery_impairment\nnutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A broken delivery route can affect one enzyme while other copper routes keep working.\norganism: Mouse\ntissue_or_cell_type: Multiple tissues and SOD1 protein\nexperimental_model: Ccs knockout mice and radiocopper labeling\nlimitations: Normal protein abundance can coexist with low activity; the phenotype does not establish a general dietary copper deficiency.\nexposure: Ccs deletion\nevidence_span: {\"source_cache\": \"artifacts/copper-research/10694572.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a8c8eb387b7e9d62e19f8de4ab12db826bbda965d5e673391bff49cb7ffe99ad\", \"start_char\": 0, \"end_char\": 1205, \"text_sha256\": \"a8c8eb387b7e9d62e19f8de4ab12db826bbda965d5e673391bff49cb7ffe99ad\"}\n[copper-p10694572] Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase. 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