{"id":"d6776c94-b138-51ee-b658-0bbd5adf899f","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-singlet-oxygen","predicate":"reacts_with","statement":"At pH 7.4, ergothioneine and hercynine generated different products after chemically generated singlet oxygen exposure.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ac40c5bd-0373-5613-8158-8c89bc8ed9f4","mechanism_event_label":"The sulfur atom changes the reaction route.","subject":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"object":{"id":"ac4a9e3e-1454-5802-82a3-3b3b18afc417","slug":"singlet-oxygen","display_name":"Singlet molecular oxygen","entity_type_key":"chemical_species"},"evidence_count":1,"mechanism_event":{"id":"ac40c5bd-0373-5613-8158-8c89bc8ed9f4","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-singlet-oxygen-event","event_type":"observed_relationship","label":"The sulfur atom changes the reaction route.","description":"At pH 7.4, ergothioneine and hercynine generated different products after chemically generated singlet oxygen exposure.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ac4a9e3e-1454-5802-82a3-3b3b18afc417","slug":"singlet-oxygen","display_name":"Singlet molecular oxygen","entity_type_key":"chemical_species"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b3583649-cbbd-50f1-be33-26b1ee0dd6ab","slug":"hercynine","display_name":"Hercynine / N-alpha-trimethylhistidine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"LC-MS analysis with a thermal singlet-oxygen donor.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Product-based reaction model; not proof that this is its exclusive physiological function.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The sulfur atom changes the reaction route.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Ergothioneine stands out from hercynine in the reaction with singlet oxygen: Resistance to glutathione and TRIS in the generation of specific products indicates high reactivity. · 2017 · https://pubmed.ncbi.nlm.nih.gov/29074402/ · DOI 10.1016/j.freeradbiomed.2017.10.372","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"cd8e2a46-d97e-5eba-903b-c05945f56c3a","evidence_kind":"source_excerpt","locator":"Lines 136-142","start_line":136,"end_line":142,"excerpt":"## ergothioneine-singlet-oxygen\nThe sulfur atom changes the reaction route.\nAt pH 7.4, ergothioneine and hercynine generated different products after chemically generated singlet oxygen exposure.\nModel: LC-MS analysis with a thermal singlet-oxygen donor.\nLimitations: Product-based reaction model; not proof that this is its exclusive physiological function.\nEvidence access: Primary abstract\nErgothioneine stands out from hercynine in the reaction with singlet oxygen: Resistance to glutathione and TRIS in the generation of specific products indicates high reactivity. · 2017 · https://pubmed.ncbi.nlm.nih.gov/29074402/ · DOI 10.1016/j.freeradbiomed.2017.10.372","model_system":"LC-MS analysis with a thermal singlet-oxygen donor.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2f037d98-f3d0-5dbe-80d8-90b738f130d6","stable_key":"import-59b18080-c560-563d-abc5-bac4ee82a27c","title":"Ergothioneine: transport, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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