{"id":"d6456480-6ec8-5a98-a8ad-3d64f991b8a0","stable_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:orexin-null-rem","predicate":"no_detected_change_in_recorded_experiment","statement":"Modafinil did not suppress direct wake-to-REM transitions in the orexin-null mouse experiment despite prolonged waking.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"cb20c5c1-392c-514d-a991-b31482f3dcb0","mechanism_event_label":"Modafinil did not suppress direct wake-to-REM transitions in the orexin-null mouse experiment despite prolonged waking.","subject":{"id":"624e6a4b-f96d-5d12-8206-30d1e1715c26","slug":"modafinil","display_name":"Modafinil","entity_type_key":"drug"},"object":{"id":"e5b72127-5823-5abe-804c-e3771abe3ab9","slug":"mouse-wake-rem-transitions","display_name":"Mouse direct wake-to-REM transitions","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"cb20c5c1-392c-514d-a991-b31482f3dcb0","stable_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:orexin-null-rem-event","event_type":"experimental_observation","label":"Modafinil did not suppress direct wake-to-REM transitions in the orexin-null mouse experiment despite prolonged waking.","description":"Orexin-null mice retained—and in one experiment showed greater—wake prolongation after modafinil. However, direct wake-to-REM transitions were not suppressed, and an EEG correlate of alertness was only partly restored. Thus, **wake duration, cataplexy-related phenomena and quality of alertness are separable**. An intact orexin system was unnecessary for one endpoint, not irrelevant to every endpoint. 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The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Modafinil did not suppress direct wake-to-REM transitions in the orexin-null mouse experiment despite prolonged waking.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Modafinil more effectively induces wakefulness in orexin-null mice than in wild-type littermates. | 2005 | DOI 10.1016/j.neuroscience.2004.10.005 | PMID 15652995 | https://pubmed.ncbi.nlm.nih.gov/15652995/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 81-81; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"fe40b7b3-f441-5486-895d-7a40b7fa9f4e","evidence_kind":"source_excerpt","locator":"Lines 81-81","start_line":81,"end_line":81,"excerpt":"Orexin-null mice retained—and in one experiment showed greater—wake prolongation after modafinil. However, direct wake-to-REM transitions were not suppressed, and an EEG correlate of alertness was only partly restored. Thus, **wake duration, cataplexy-related phenomena and quality of alertness are separable**. An intact orexin system was unnecessary for one endpoint, not irrelevant to every endpoint. [Orexin-null experiment](https://pubmed.ncbi.nlm.nih.gov/15652995/)","model_system":"Orexin-null mice; wake duration, direct REM transitions and EEG alertness differ.","directness":"reported_statement","verification_status":"source_recorded","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. 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