{"id":"d6254400-1b68-54ee-8b18-a93fc4110b7b","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:thiamine-def-motor-neuropathy-pattern","predicate":"deficiency-associated-with","statement":"Most nonalcoholic thiamine-deficiency neuropathy cases showed motor-dominant, relatively acute progression, unlike the more slowly progressive sensory-dominant pure alcoholic-neuropathy group.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"e3c8fac5-cb74-5843-8f12-15828010b82a","mechanism_event_label":"Thiamine-related nerve injury and alcohol-related nerve injury showed different typical clinical patterns.","subject":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"object":{"id":"41e7c99d-df21-5ace-a189-c91ff2141c8d","slug":"peripheral-motor-neuropathy","display_name":"Motor-dominant peripheral neuropathy","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e3c8fac5-cb74-5843-8f12-15828010b82a","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:thiamine-def-motor-neuropathy-pattern-event","event_type":"observed_intervention","label":"Thiamine-related nerve injury and alcohol-related nerve injury showed different typical clinical patterns.","description":"Most nonalcoholic thiamine-deficiency neuropathy cases showed motor-dominant, relatively acute progression, unlike the more slowly progressive sensory-dominant pure alcoholic-neuropathy group.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"41e7c99d-df21-5ace-a189-c91ff2141c8d","slug":"peripheral-motor-neuropathy","display_name":"Motor-dominant peripheral neuropathy","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Thiamine-related nerve injury and alcohol-related nerve injury showed different typical clinical patterns.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[koike-2003-neuropathy-subtypes] Alcoholic neuropathy is clinicopathologically distinct from thiamine-deficiency neuropathy (2003). https://pubmed.ncbi.nlm.nih.gov/12838517/ DOI: 10.1002/ana.10550","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Peripheral neurological examination","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"264aeee5-2fbc-59bb-a865-d0f768b6358d","evidence_kind":"source_excerpt","locator":"Lines 1535-1547","start_line":1535,"end_line":1547,"excerpt":"### thiamine-def-motor-neuropathy-pattern\nMost nonalcoholic thiamine-deficiency neuropathy cases showed motor-dominant, relatively acute progression, unlike the more slowly progressive sensory-dominant pure alcoholic-neuropathy group.\nCondition category: nutrient_deficiency\nnutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Thiamine-related nerve injury and alcohol-related nerve injury showed different typical clinical patterns.\norganism: Homo sapiens\ntissue_or_cell_type: Peripheral neurological examination\nexperimental_model: Clinical and sural-nerve pathology comparison of 64 alcoholic-neuropathy patients subdivided by coexisting thiamine deficiency and 32 nonalcoholic thiamine-deficiency neuropathy patients.\nlimitations: Observational referral cohort; mixed alcohol-plus-deficiency cases had overlapping features, so phenotype alone cannot determine cause.\nevidence_location: Abstract: clinical comparison\nevidence_span: motor-dominant and acutely progressive pattern\nexposure: Nonalcoholic thiamine-deficiency neuropathy identified in a clinical cohort\n[koike-2003-neuropathy-subtypes] Alcoholic neuropathy is clinicopathologically distinct from thiamine-deficiency neuropathy (2003). https://pubmed.ncbi.nlm.nih.gov/12838517/ DOI: 10.1002/ana.10550","model_system":"Clinical and sural-nerve pathology comparison of 64 alcoholic-neuropathy patients subdivided by coexisting thiamine deficiency and 32 nonalcoholic thiamine-deficiency neuropathy patients.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [koike-2003-neuropathy-subtypes] Alcoholic neuropathy is clinicopathologically distinct from thiamine-deficiency neuropathy (2003). https://pubmed.ncbi.nlm.nih.gov/12838517/ DOI: 10.1002/ana.10550","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"158d2c03-ac8c-589f-8270-c468165ae346","stable_key":"import-46d15d9e-d3b5-544d-ba01-b785aa3e4f42","title":"Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"f376512fb3310141315548015b387833e3af45146e73fb73cd02cee20e4ddb9c","revision_id":"53bc5eda-dec8-58cc-a56f-a9eb4ab036ef","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}