{"id":"d5e5a330-593a-528d-9176-2b25f6bddf11","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-photosensitizer-context","predicate":"context_changes_inhibition","statement":"With a lipid-soluble photosensitizer in bilayers, astaxanthin was more stable yet less inhibitory than beta-carotene.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e57893e4-4ce6-530e-98e6-0c51b124e3bd","mechanism_event_label":"Greater chemical stability did not guarantee greater protection.","subject":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"object":{"id":"f00627d2-4857-5c63-81af-71cde3768d38","slug":"lipid-peroxidation","display_name":"Lipid peroxidation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e57893e4-4ce6-530e-98e6-0c51b124e3bd","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-photosensitizer-context-event","event_type":"observed_relationship","label":"Greater chemical stability did not guarantee greater protection.","description":"With a lipid-soluble photosensitizer in bilayers, astaxanthin was more stable yet less inhibitory than beta-carotene.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f00627d2-4857-5c63-81af-71cde3768d38","slug":"lipid-peroxidation","display_name":"Lipid peroxidation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"73c24cd4-9ae8-5897-8359-fa4d9e8edecb","slug":"beta-carotene","display_name":"All-trans-beta-carotene","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Photosensitized model lipid bilayers.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Oxidant source and position differ from other assays; this is context dependence, not an error requiring a universal ranking.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Astaxanthin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Greater chemical stability did not guarantee greater protection.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Inhibitory effect of beta-carotene and astaxanthin on photosensitized oxidation of phospholipid bilayers. · 1993 · https://pubmed.ncbi.nlm.nih.gov/8006717/ · DOI 10.3177/jnsv.39.607","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"40779e4e-1c26-520a-9a58-58d7c8818162","evidence_kind":"source_excerpt","locator":"Lines 166-172","start_line":166,"end_line":172,"excerpt":"## astaxanthin-photosensitizer-context\nGreater chemical stability did not guarantee greater protection.\nWith a lipid-soluble photosensitizer in bilayers, astaxanthin was more stable yet less inhibitory than beta-carotene.\nModel: Photosensitized model lipid bilayers.\nLimitations: Oxidant source and position differ from other assays; this is context dependence, not an error requiring a universal ranking.\nEvidence access: Primary abstract\nInhibitory effect of beta-carotene and astaxanthin on photosensitized oxidation of phospholipid bilayers. · 1993 · https://pubmed.ncbi.nlm.nih.gov/8006717/ · DOI 10.3177/jnsv.39.607","model_system":"Photosensitized model lipid bilayers.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4fd91ea6-78b4-5bfe-93e3-686fbef9f678","stable_key":"import-a8bedee0-a740-5bbb-921e-bfd144c7b68c","title":"Astaxanthin: transport, membrane chemistry, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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