{"id":"d51710cb-5cc8-5176-8bda-3855f5daed7f","stable_key":"e1af6d55-ced5-56c9-9a2d-8cc2ae6ec3ff:nasunin-peroxide-lipid-protection","predicate":"reduced","statement":"Nasunin below 50 micromolar reduced peroxide-induced lipid-peroxidation readouts in rat brain homogenates.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8a587909-d57f-5899-bfce-f63aeb5d200b","mechanism_event_label":"This is a biochemical protection result, not a brain-treatment trial.","subject":{"id":"6553997f-f098-5507-95b4-0fdb8aac491d","slug":"nasunin","display_name":"Nasunin","entity_type_key":"small_molecule"},"object":{"id":"f00627d2-4857-5c63-81af-71cde3768d38","slug":"lipid-peroxidation","display_name":"Lipid peroxidation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8a587909-d57f-5899-bfce-f63aeb5d200b","stable_key":"e1af6d55-ced5-56c9-9a2d-8cc2ae6ec3ff:nasunin-peroxide-lipid-protection-event","event_type":"biochemical_relationship","label":"This is a biochemical protection result, not a brain-treatment trial.","description":"Nasunin below 50 micromolar reduced peroxide-induced lipid-peroxidation readouts in rat brain homogenates.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"da9d64bc-69d4-5d97-90a4-8f0ed03e0ac8","slug":"hydrogen-peroxide","display_name":"Hydrogen peroxide","entity_type_key":"small_molecule"},"role":"challenge","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6553997f-f098-5507-95b4-0fdb8aac491d","slug":"nasunin","display_name":"Nasunin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f00627d2-4857-5c63-81af-71cde3768d38","slug":"lipid-peroxidation","display_name":"Lipid peroxidation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/nasunin-research/10962130.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"61b195a6eff14c25cfc341069c7cafb8fe4d0b374aa294b3d28e0e48bbed7c16\", \"start_char\": 0, \"end_char\": 1706, \"text_sha256\": \"61b195a6eff14c25cfc341069c7cafb8fe4d0b374aa294b3d28e0e48bbed7c16\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"DMPO-competition ESR assay and peroxide challenge","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Variable DMPO concentrations; nasunin below 50 micromolar in homogenate experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Related investigators and overlapping numerical results with the 1998 report; not independent replication. Ferrous-chelation interpretation is distinct from the earlier Fe(III) stoichiometry experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Nasunin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"nasunin","display_name":"Nasunin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Cell-free reaction and rat brain homogenate","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"This is a biochemical protection result, not a brain-treatment trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[nasunin-p10962130] Antioxidant activity of nasunin, an anthocyanin in eggplant peels. (2000). https://pubmed.ncbi.nlm.nih.gov/10962130/ DOI: 10.1016/s0300-483x(00)00202-x","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Fenton chemistry and lipid-peroxidation markers","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"466e50b0-d9e4-5dab-bf0e-69cfafe99c57","evidence_kind":"source_excerpt","locator":"Lines 588-599","start_line":588,"end_line":599,"excerpt":"### nasunin-peroxide-lipid-protection\nNasunin below 50 micromolar reduced peroxide-induced lipid-peroxidation readouts in rat brain homogenates.\nCondition category: normal\nnutrient_topic: Nasunin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: This is a biochemical protection result, not a brain-treatment trial.\norganism: Cell-free reaction and rat brain homogenate\ntissue_or_cell_type: Fenton chemistry and lipid-peroxidation markers\nexperimental_model: DMPO-competition ESR assay and peroxide challenge\nlimitations: Related investigators and overlapping numerical results with the 1998 report; not independent replication. Ferrous-chelation interpretation is distinct from the earlier Fe(III) stoichiometry experiment.\nexposure: Variable DMPO concentrations; nasunin below 50 micromolar in homogenate experiments\nevidence_span: {\"source_cache\": \"artifacts/nasunin-research/10962130.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"61b195a6eff14c25cfc341069c7cafb8fe4d0b374aa294b3d28e0e48bbed7c16\", \"start_char\": 0, \"end_char\": 1706, \"text_sha256\": \"61b195a6eff14c25cfc341069c7cafb8fe4d0b374aa294b3d28e0e48bbed7c16\"}\n[nasunin-p10962130] Antioxidant activity of nasunin, an anthocyanin in eggplant peels. (2000). https://pubmed.ncbi.nlm.nih.gov/10962130/ DOI: 10.1016/s0300-483x(00)00202-x","model_system":"DMPO-competition ESR assay and peroxide challenge","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [nasunin-p10962130] Antioxidant activity of nasunin, an anthocyanin in eggplant peels. (2000). https://pubmed.ncbi.nlm.nih.gov/10962130/ DOI: 10.1016/s0300-483x(00)00202-x","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2c43df19-ccb0-58f1-b9a4-bc92cda6de5a","stable_key":"import-e1af6d55-ced5-56c9-9a2d-8cc2ae6ec3ff","title":"Nasunin: identity, redox chemistry and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"56552c208433294bf9a6c95513d981dbe4d00fd8336c121816d7b8bd6604d50e","revision_id":"b0296d49-32d7-52dc-a23c-5e862da0fba3","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}