{"id":"d4ff7e3b-5c00-515d-9839-87e150b27fc9","stable_key":"4fef8d72-f107-5eb5-b2fb-483ca85465e0:k2-dietary-k-prothrombin","predicate":"restriction_reduces","statement":"Dietary K1 restriction reduced prothrombin and osteocalcin gamma-carboxylation and lowered plasma K1 and urinary Gla excretion.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"3e5df8ee-6311-5c6b-b429-7b905ed30030","mechanism_event_label":"A shortfall can appear in protein-modification markers before it is described as a clinical syndrome.","subject":{"id":"5f9fd13b-5428-5024-a855-9db526855890","slug":"phylloquinone","display_name":"Phylloquinone","entity_type_key":"small_molecule"},"object":{"id":"de0220e7-19ea-5b7e-8521-57abbfe8e945","slug":"vitamin-k-dependent-carboxylation","display_name":"Vitamin K-dependent protein gamma-carboxylation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3e5df8ee-6311-5c6b-b429-7b905ed30030","stable_key":"4fef8d72-f107-5eb5-b2fb-483ca85465e0:k2-dietary-k-prothrombin-event","event_type":"biochemical_relationship","label":"A shortfall can appear in protein-modification markers before it is described as a clinical syndrome.","description":"Dietary K1 restriction reduced prothrombin and osteocalcin gamma-carboxylation and lowered plasma K1 and urinary Gla excretion.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7831d47f-191c-5515-8202-534bc962e1ad","slug":"f2","display_name":"Prothrombin / coagulation factor II / F2","entity_type_key":"protein"},"role":"hepatic_protein","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b043ce5c-8537-5099-8421-b07ec993dbde","slug":"bglap","display_name":"Osteocalcin / BGLAP","entity_type_key":"protein"},"role":"extrahepatic_protein","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5f9fd13b-5428-5024-a855-9db526855890","slug":"phylloquinone","display_name":"Phylloquinone","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"de0220e7-19ea-5b7e-8521-57abbfe8e945","slug":"vitamin-k-dependent-carboxylation","display_name":"Vitamin K-dependent protein gamma-carboxylation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/k2-research/12888638.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c57beda0b2c7bdc471fd6f4bfa926e9f12846f040c95689648f599d6cceae874\", \"start_char\": 0, \"end_char\": 1461, \"text_sha256\": \"c57beda0b2c7bdc471fd6f4bfa926e9f12846f040c95689648f599d6cceae874\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Metabolic-unit dietary depletion/repletion","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"K1 restricted to 18 micrograms/day for 28 days, then stepped repletion","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The measured endpoint is carboxylation, not an observed clinical clotting failure; restricted-K1 exposure does not define isolated K2 deficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"k2","display_name":"Vitamin K2 / menaquinone family","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"21 women aged 60–80 years","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A shortfall can appear in protein-modification markers before it is described as a clinical syndrome.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[k2-p12888638] Dietary phylloquinone depletion and repletion in older women. (2003). https://pubmed.ncbi.nlm.nih.gov/12888638/ DOI: 10.1093/jn/133.8.2565","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Hepatic and extrahepatic protein markers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"9b541890-2e58-5ce3-ad17-37398309ede6","evidence_kind":"source_excerpt","locator":"Lines 1007-1018","start_line":1007,"end_line":1018,"excerpt":"### k2-dietary-k-prothrombin\nDietary K1 restriction reduced prothrombin and osteocalcin gamma-carboxylation and lowered plasma K1 and urinary Gla excretion.\nCondition category: nutrient_deficiency\nnutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A shortfall can appear in protein-modification markers before it is described as a clinical syndrome.\norganism: 21 women aged 60–80 years\ntissue_or_cell_type: Hepatic and extrahepatic protein markers\nexperimental_model: Metabolic-unit dietary depletion/repletion\nlimitations: The measured endpoint is carboxylation, not an observed clinical clotting failure; restricted-K1 exposure does not define isolated K2 deficiency.\nexposure: K1 restricted to 18 micrograms/day for 28 days, then stepped repletion\nevidence_span: {\"source_cache\": \"artifacts/k2-research/12888638.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c57beda0b2c7bdc471fd6f4bfa926e9f12846f040c95689648f599d6cceae874\", \"start_char\": 0, \"end_char\": 1461, \"text_sha256\": \"c57beda0b2c7bdc471fd6f4bfa926e9f12846f040c95689648f599d6cceae874\"}\n[k2-p12888638] Dietary phylloquinone depletion and repletion in older women. 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