{"id":"d4f0fc88-74e0-569b-9d4f-32216a2eba74","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-olanzapine-mouse-pool","predicate":"associated_with_reduction","statement":"Chronic olanzapine treatment in mice reduced blood and brain ergothioneine alongside altered microbiota and cognitive deficits.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"1682dd54-f377-5977-885f-92cb7da05256","mechanism_event_label":"A medicine-associated ecosystem change coincided with a lower pool.","subject":{"id":"e83902e5-cd44-5de2-b790-abf19033d265","slug":"olanzapine","display_name":"Olanzapine","entity_type_key":"small_molecule"},"object":{"id":"70f91c4c-f791-523f-8bbb-93c254bd0f79","slug":"mouse-brain-ergothioneine","display_name":"Mouse brain ergothioneine concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1682dd54-f377-5977-885f-92cb7da05256","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-olanzapine-mouse-pool-event","event_type":"observed_relationship","label":"A medicine-associated ecosystem change coincided with a lower pool.","description":"Chronic olanzapine treatment in mice reduced blood and brain ergothioneine alongside altered microbiota and cognitive deficits.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e83902e5-cd44-5de2-b790-abf19033d265","slug":"olanzapine","display_name":"Olanzapine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"70f91c4c-f791-523f-8bbb-93c254bd0f79","slug":"mouse-brain-ergothioneine","display_name":"Mouse brain ergothioneine concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; 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unverified.","entity":null}],"evidence":[{"id":"00d23916-0bf7-536d-8a61-0f91c16566db","evidence_kind":"source_excerpt","locator":"Lines 424-430","start_line":424,"end_line":430,"excerpt":"## ergothioneine-olanzapine-mouse-pool\nA medicine-associated ecosystem change coincided with a lower pool.\nChronic olanzapine treatment in mice reduced blood and brain ergothioneine alongside altered microbiota and cognitive deficits.\nModel: Mouse treatment, multi-omics and microbiota-transplant experiments.\nLimitations: Association among microbial taxa and metabolite levels does not resolve every biosynthetic flux.\nEvidence access: Primary abstract\nGut microbiota-derived ergothioneine alleviates antipsychotic-induced synaptic and cognitive impairments. · 2026 · https://pubmed.ncbi.nlm.nih.gov/42013837/ · DOI 10.1016/j.chom.2026.03.020","model_system":"Mouse treatment, multi-omics and microbiota-transplant experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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