{"id":"d4ca667d-cad8-5d46-99c1-1690d98175d1","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-clock-mouse","predicate":"lengthens","statement":"Lithium-associated period lengthening accompanied altered SCN GSK3 expression and phosphorylation in mice.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e53c47cd-8eec-5a09-8026-0528a7cf4815","mechanism_event_label":"A brain clock and its signaling proteins changed together.","subject":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"object":{"id":"baadf7e1-4ff0-595b-84cd-84cff220f9a6","slug":"mouse-locomotor-circadian-period","display_name":"Mouse locomotor circadian period","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e53c47cd-8eec-5a09-8026-0528a7cf4815","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-clock-mouse-event","event_type":"observed_relationship","label":"A brain clock and its signaling proteins changed together.","description":"Lithium-associated period lengthening accompanied altered SCN GSK3 expression and phosphorylation in mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"baadf7e1-4ff0-595b-84cd-84cff220f9a6","slug":"mouse-locomotor-circadian-period","display_name":"Mouse locomotor circadian period","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e2e3902-5e26-52e3-9c85-1d7c0ace1637","slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e7b85cc5-eead-5551-ba6d-40420edd8156","slug":"mouse-gsk3b","display_name":"Mouse glycogen synthase kinase 3 beta / Gsk3b","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse locomotor monitoring and suprachiasmatic-nucleus assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Association does not establish that GSK3 is the sole circadian target.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"A brain clock and its signaling proteins changed together.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effect of lithium on the circadian rhythms of locomotor activity and glycogen synthase kinase-3 protein expression in the mouse suprachiasmatic nuclei. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15090054/ · DOI 10.1111/j.0953-816X.2004.03322.x","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0360458b-5b47-5969-8721-9c9a8a214718","evidence_kind":"source_excerpt","locator":"Lines 256-262","start_line":256,"end_line":262,"excerpt":"## lithium-clock-mouse\nA brain clock and its signaling proteins changed together.\nLithium-associated period lengthening accompanied altered SCN GSK3 expression and phosphorylation in mice.\nModel: Mouse locomotor monitoring and suprachiasmatic-nucleus assays.\nLimitations: Association does not establish that GSK3 is the sole circadian target.\nEvidence access: Primary abstract\nEffect of lithium on the circadian rhythms of locomotor activity and glycogen synthase kinase-3 protein expression in the mouse suprachiasmatic nuclei. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15090054/ · DOI 10.1111/j.0953-816X.2004.03322.x","model_system":"Mouse locomotor monitoring and suprachiasmatic-nucleus assays.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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